Objective The project will focus on the design and chemical synthesis of various new compounds (including 2',3'-dideoxynucleoside analogues, phosphonate derivatives thereof, acyclic nucleosides, anthracycline and streptonigrin derivatives, and quinoxalines), which will then be evaluated in Leuven for their antiviral and antitumor activity. A wide variety of viruses (including influenza and other respiratory viruses, herpes simplex virus, varicella-zoster virus, cytomegalovirus, human immunodeficiency virus and other retroviruses) and tumour such as leukemia, lymphoma, carcinoma, cell systems will be included in this project. In addition, a series of mutant viruses and tumour cell lines, for which the mutations and/or enzyme defects are well-characterised, will be included in the evaluation of the novel compounds to allow more insight into the molecular interaction of the test compounds with their target enzymes (proteins) and/or the metabolic pathways involved to convert the test compounds to their metabolically active form. The chemical part of the project will be carried out by the five NIS partners and in the U.K. the biological part will fall under the responsibility of th Leuven group. Programme(s) IC-INTAS - International Association for the promotion of cooperation with scientists from the independent states of the former Soviet Union (INTAS), 1993- Topic(s) 45 - Pharmacology Call for proposal Data not available Funding Scheme Data not available Coordinator Katholieke Universiteit Leuven EU contribution No data Address Minderbroedersstraat 10 3000 Leuven Belgium See on map Total cost No data Participants (5) Sort alphabetically Sort by EU Contribution Expand all Collapse all Academy of Sciences of Belarus Belarus EU contribution No data Address 220141 Minsk See on map Total cost No data Russian Academy of Sciences Russia EU contribution No data Address 119867 Moscow See on map Total cost No data UNIVERSITY OF WALES CARDIFF United Kingdom EU contribution No data Address King Edward VII Avenue, Redwood Building CF10 3XF CARDIFF See on map Total cost No data Urals State Technical University Russia EU contribution No data Address 620002 Yekaterinburg See on map Total cost No data Volgograd Medicinal Institute Russia EU contribution No data Address 400066 Volgograd See on map Total cost No data
