Objective An avalanche of data has been gathered by the various genome mapping and sequencing projects. This data combined with the biological information in databases has an inestimable potential value. The realization of that potential is heavily dependent on investments in the development of tools to make use of the underlying data in databases and to make this knowledge available to the scientific community. Protein sequence databases form a key computational resource for modern molecular biology. Searches against such a database frequently allow transfer of important functional information to a new sequence. However, transferring information from pairwise hits to other sequences is prone to error, particularly when this must be done on a large scale, for instance when annotating predicted genes from genome projects at the genome centres or when annotating sequences for inclusion in databases like SWISS-PROT + TREMBL. In recognition of these limitations, it is now essential to extend search strategies to include a range of "secondary" databases when analysing novel protein sequences. Databases on functional sites and domains like PROSITE, PRINTS, PFAM, PRODOM, BLOCKS, etc., have become vital resources for identifying distant relationships in novel sequences, and hence for predicting protein function and structure. Unfortunately, these secondary databases do not share the same formats and nomenclature, which makes the use of all of them in an automated way difficult. In response to this the partners in this proposal (EBI, University of Geneva, ISREC, UCL, Sanger Centre, INRIA, CNRS/INRA, Compugen, LION, Pfizer and University of Bergen) want to address these problems by establishing an Integrated resource of Protein domains and functional sites (InterPro), and to apply this resource to accelerate protein functional analysis. This will create the pre-eminent world-wide secondary database for protein annotation. The main objectives and goals of this proposal are: - Creation of InterPro, allowing users to access a wider, complementary range of site and domain recognition methods in a single package. - Establishment of WWW servers which allow the scientific community to useInterPro in protein sequence analysis. - Incorporation of InterPro in the computer-generation of annotation in TREMBL,the protein database supplementing SWISS-PROT. - Use of InterPro in the annotation of predicted genes from genome projects. Fields of science natural sciencescomputer and information sciencesdatabasesnatural sciencesbiological sciencesbiochemistrybiomoleculesproteinsnatural sciencesmathematicspure mathematicsmathematical analysisfunctional analysisnatural sciencesbiological sciencesgeneticsgenomesnatural sciencesbiological sciencesmolecular biology Programme(s) FP4-BIOTECH 2 - Specific research, technological development and demonstration programme in the field of biotechnology, 1994-1998 Topic(s) 080101 - Information resources on molecular sequences and structures Call for proposal Data not available Funding Scheme CSC - Cost-sharing contracts Coordinator EUROPEAN MOLECULAR BIOLOGY LABORATORY EU contribution No data Address Wellcome Trust Genome Campus, Hinxton Hall CB10 1SD SAFFRON WALDEN United Kingdom See on map Total cost No data Participants (7) Sort alphabetically Sort by EU Contribution Expand all Collapse all CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE France EU contribution No data Address Chemin de Borde-Rouge INRA 31326 AUREVILLE See on map Total cost No data GENE-IT S.A. France EU contribution No data Address 3,Rue du Chant des Oiseaux 5 78360 MONTESSON See on map Total cost No data GENOME RESEARCH LTD. United Kingdom EU contribution No data Address The Wellcome Trust Genome Campus Hinxton CB10 1SA SAFFRON WALDEN See on map Total cost No data INSTITUT SUISSE DE RECHERCHES EXPERIMENTALES SUR LE CANCER Switzerland EU contribution No data Address 155,CH. DES BOVERESSES 155 1066 EPALINGES See on map Total cost No data LION Bioscience AG Germany EU contribution No data Address 515-517,Im Neuenheimer Feld 69120 Heidelberg See on map Total cost No data SWISS INSTITUTE OF BIOINFORMATICS Switzerland EU contribution No data Address 1,CMU, Rue Michel Servet 1 1211 GENEVE See on map Total cost No data UNIVERSITY OF BERGEN Norway EU contribution No data Address 55,Thormohlensgaten 55, Bergen High Technology Centre 5020 BERGEN See on map Total cost No data
