The consortium project is to investigate the role of connexins in the physio(patho)logy of heart and vessels , and their involvment in the early pathogenesis of major cardiovascular disease, by an experimental approach to which aim European teams will contribute. One of the essential pathways of the intercellula signalling network which underlies the functions of all the tissues is the cell to cell coupling by means of specialized menbrane channels composed of connexins. In the diverse tissues of the cardiovascular system the cells are connected by these channels which mediate signals controlling functions as,distinct as,e.g. the coordinated contraction of myocytes or smooth muscle cells or migration and growth of endothelial cells . Dysregulation of the connexin channels interferes with the functions of the cardiovascular system : conversely chronic alteration of these functions (e.g fibrillation,hypertension) induces cells-specific changes in connexin expression elther in heart or in vascular wall.
Funding SchemeCSC - Cost-sharing contracts
35760 Saint Gregoire