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Intercellular signalling through connexin channels : a key to the understanding of cardiovascular research

Objective

The consortium project is to investigate the role of connexins in the physio(patho)logy of heart and vessels , and their involvment in the early pathogenesis of major cardiovascular disease, by an experimental approach to which aim European teams will contribute. One of the essential pathways of the intercellula signalling network which underlies the functions of all the tissues is the cell to cell coupling by means of specialized menbrane channels composed of connexins. In the diverse tissues of the cardiovascular system the cells are connected by these channels which mediate signals controlling functions as,distinct as,e.g. the coordinated contraction of myocytes or smooth muscle cells or migration and growth of endothelial cells . Dysregulation of the connexin channels interferes with the functions of the cardiovascular system : conversely chronic alteration of these functions (e.g fibrillation,hypertension) induces cells-specific changes in connexin expression elther in heart or in vascular wall.

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
Address
Campus De Luminy, Case 907 163 Avenue De Luminy.
13288 Marseille
France

Participants (8)

IMPERIAL COLLEGE OF SCIENCE, TECHNOLOGY AND MEDICINE
United Kingdom
Address
Dovehouse Street
London
INSTITUTO NACIONAL DE LA SALUD
Spain
Address
Carretera De Colmenar, Km 9
28034 Madrid
RHEINISCHE FRIEDRICH-WILHELMS-UNIVERSITAET BONN
Germany
Address
Regina Pacis Weg 3
Bonn
SMITHKLINE BEECHAM LABORATOIRES PHARMACEUTIQUES
France
Address
4 Rue Du Chesnay Beauregard
35760 Saint Gregoire
UNIVERSITE DE POITIERS
France
Address
Rue De Blossac 15
86034 Poitiers
UNIVERSITY OF BERNE
Switzerland
Address
5,Hochschulstrasse 4
3012 Bern
UNIVERSITY OF GENEVA
Switzerland
Address
24,Rue General Dufour 24
1211 Geneve
WISE & MUNRO LEARNING RESEARCH
Netherlands
Address
8,Azaleastraat 85
2565 CD Den Haag