Objetivo There is a pressing need for more effective treatments for chronic degenerative diseases such as rheumatoid arthritis (RA) and inflammatory bowel disease (IBD) This proposal aims to resolve the molecular mechanisms which underlie these diseases by focusing on the highly novel family of toll-like receptors TLRs) whose members have been linked with onset and progression of inflammatory diseases The proposal plans to explore all aspects of TLR biology, from regulation of their expression, to mechanism of action, to role in inflammatory diseases Several key technologies will be used, including the generation of knockout mice, animal model of disease, analysis of clinical samples, genomics and is predicted that such a multidisciplinary approach will define the role of TLRS in RA and IBD and will suggest new therapies fore these debilitaing diseases Ámbito científico natural sciencesbiological sciencesgeneticsmedical and health sciencesclinical medicinerheumatologymedical and health scienceshealth sciencesinflammatory diseasesmedical and health sciencesclinical medicinegastroenterologyinflammatory bowel disease Programa(s) FP5-LIFE QUALITY - Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002 Tema(s) 1.1.1.-7. - Chronic and degenerative diseases, cancer, diabetes, cardivascular diseases and rare diseases Convocatoria de propuestas Data not available Régimen de financiación CSC - Cost-sharing contracts Coordinador NATIONAL UNIVERSITY OF IRELAND, DUBLIN Aportación de la UE Sin datos Dirección Belfield 4 DUBLIN Irlanda Ver en el mapa Coste total Sin datos Participantes (5) Ordenar alfabéticamente Ordenar por aportación de la UE Ampliar todo Contraer todo GLAXOSMITHKLINE RESEARCH AND DEVELOPMENT LIMITED Reino Unido Aportación de la UE Sin datos Dirección Great West Road 980 TW8 9GS BRENTFORD Ver en el mapa Coste total Sin datos MARIO NEGRI INSTITUTE FOR PHARMACOLOGICAL RESEARCH Italia Aportación de la UE Sin datos Dirección Via Eritrea 62 20157 MILANO Ver en el mapa Enlaces Sitio web Opens in new window Coste total Sin datos THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE Reino Unido Aportación de la UE Sin datos Dirección Trinity Lane, The Old Schools, CB2 1TN CAMBRIDGE Ver en el mapa Coste total Sin datos THE PROVOST, FELLOWS AND SCHOLARS OF THE COLLEGE OF THE HOLY AND UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN HEREINAFTER TRINITY COLLEGE DUBLIN Irlanda Aportación de la UE Sin datos Dirección Trinity College 2 DUBLIN Ver en el mapa Coste total Sin datos UNIVERSITAET REGENSBURG Alemania Aportación de la UE Sin datos Dirección UNIVERSITAETSSTRASSE 31 REGENSBURG Ver en el mapa Enlaces Sitio web Opens in new window Coste total Sin datos
