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Fast interpretation of nmr data for structural and functional analysis of proteins

Fast interpretation of nmr data for structural and functional analysis of proteins

Objective

A tested and validated NMR toolkit for the fast determination of protein structures, in particular for proteins containing new folds, is developed in the project. The time needed to find a novel protein fold will be reduced by at least a factor of five over current procedures, by using automated techniques for the determination of secondary and tertiary structure and the integration of NMR, proteins expression and bio-informatics procedures. In the NMR structure determination NMR parameters depending on the partial alignment of the protein solute, i.e. residual dipolar coupling, chemical shift anisotropy and paramagnetic effects, and croscorrelation effects will be used to J-couplings and NOE's.

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Coordinator

WISE & MUNRO LEARNING RESEARCH

Address

8,Azaleastraat 85
2565 Cd Den Haag

Netherlands

Administrative Contact

Paul G.C. HERMANS (Dr)

Participants (7)

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AVENTIS RESEARCH & TECHNOLOGIES GMBH & CO KG

Germany

CONSORZIO INTERUNIVERSITARIO RISONANZE MAGNETICHE DI METALLOPROTEINE PARAMAGNETICHE

Italy

EUROPEAN MOLECULAR BIOLOGY LABORATORY

Germany

JOHANN WOLFGANG GOETHE UNIVERSITAET FRANKFURT

Germany

N.V. ORGANON

Netherlands

SMITHKLINE BEECHAM PLC

United Kingdom

University of East Anglia

United Kingdom

Project information

Grant agreement ID: QLG2-CT-1999-01003

  • Start date

    1 February 2000

  • End date

    31 January 2004

Funded under:

FP5-LIFE QUALITY

  • Overall budget:

    € 1 522 000

  • EU contribution

    € 1 499 500

Coordinated by:

WISE & MUNRO LEARNING RESEARCH

Netherlands