Objetivo Neuro-degenerative diseases represent a major social and economic problem for the Community; they are characterised by the cell death of specific populations of neurons. No cures currently exist: good candidates would be drugs that inhibit intracellular signalling pathways involved in cell death, or stimulate signalling for survival, but we know little about how the pathways are regulated in neurons in normal or pathological situations. Our transnational project involving academic, clinical and industrial partners is aimed at a better understanding of the role of several novel mechanisms. We will study in neurons the control mechanisms and signalling pathways involved. We aim to generate important new data in this fast-moving field, and to define novel potential targets for drug discovery.The project was successful in achieving the majority of its main objectives, and the continuous interaction between groups in a fast-moving field led to many results and publications (nealry 80 in international peer-reviewed journals) that could not have been predicted at the start of the project.Our major findings were:1. We discovered new intracellular signalling pathways that regulate neuronal death or survival. These may be useful targets for therapeutic intervention in patients;2. We demonstrated unexpected roles for neurotrophic factors in development and functioning of the nervous system. These open new avenues of potential application for these factors and also inform of potential side effects;3. We found that signalling pathways interact in complex manners to determine the development, survival or death of specific neuronal populations within the nervous system. This is likely to have repercussions for the design of neuroprotective strategies in patients;4. We demonstrated that, in addition to external triggers, the death or survival of a given neuron is strongly regulated by intrinsic determinants. This may explain the selective loss of certain neurons in patients with neurodegenerative disease. Ámbito científico natural sciencesbiological sciencesneurobiologymedical and health sciencesbasic medicinepharmacology and pharmacydrug discoverynatural sciencesbiological sciencescell biologycell signaling Programa(s) FP5-LIFE QUALITY - Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002 Tema(s) 1.1.1.-9. - Neurosciences Convocatoria de propuestas Data not available Régimen de financiación CSC - Cost-sharing contracts Coordinador INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE Aportación de la UE Sin datos Dirección Campus de Luminy ADR 2 - Provence, Alpes, Côte d'A 13288 Marseille Francia Ver en el mapa Coste total Sin datos Participantes (7) Ordenar alfabéticamente Ordenar por aportación de la UE Ampliar todo Contraer todo CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE Francia Aportación de la UE Sin datos Dirección Rue de la Cardonille 141 34094 Montpellier Ver en el mapa Coste total Sin datos INSTITUT CATALA DE LA SALUT España Aportación de la UE Sin datos Dirección Paseo Valle de Hebron 119-129 08035 BARCELONA Ver en el mapa Coste total Sin datos KAROLINSKA INSTITUTE Suecia Aportación de la UE Sin datos Dirección Solnavagen 1 171 77 STOCKHOLM Ver en el mapa Coste total Sin datos MAX PLANCK GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V. Alemania Aportación de la UE Sin datos Dirección Hofgartenstrasse 8 MUENCHEN Ver en el mapa Enlaces Sitio web Opens in new window Coste total Sin datos UNIVERSIDAD DE LLEIDA España Aportación de la UE Sin datos Dirección Placa Victor Siurana 1 - LLEIDA 25003 LERIDA Ver en el mapa Coste total Sin datos UNIVERSITY OF GENEVA Suiza Aportación de la UE Sin datos Dirección 30,Quai Ernest Ausermet 30 1211 GENEVE Ver en el mapa Coste total Sin datos University of Edinburgh Reino Unido Aportación de la UE Sin datos Dirección Old College South Bridge EH1 1HN Edinburgh Ver en el mapa Coste total Sin datos
