Obiettivo This proposal comprises two specific research thrusts. First, to support the development of fibrin micro beads (FMB) to enhance soft tissue repair and provide new cell delivery vehicles. In this thrust, most of our efforts will be focused on evaluating the use of plasma derived FMB for tissue engineering. For both mechanistic insights as well as potentially improved product safety, we will also evaluate r-FMB using recombinant fibrinogen derived from sheep milk, licensed from PPL to Smith & Nephew, for exploitation in tissue repair. In the second thrust the consortium will address the basic biochemistry of fibrinogen and related clotting factors (thrombin and factor XIII) in wound healing, supported by preclinical studies to assess in vivo activity. Comparisons with recombinant analogues will be made. Campo scientifico natural sciencesbiological sciencesbiochemistrymedical and health sciencesmedical biotechnologytissue engineeringmedical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsvaccines Programma(i) FP5-LIFE QUALITY - Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002 Argomento(i) 1.1.1.-2. - Key action Control of Infectious Diseases Invito a presentare proposte Data not available Meccanismo di finanziamento CSC - Cost-sharing contracts Coordinatore UNIVERSITY OF ERLANGEN-NUREMBERG Contributo UE Nessun dato Indirizzo Wasserturmstraße 3 91054 ERLANGEN Germania Mostra sulla mappa Costo totale Nessun dato Partecipanti (3) Classifica in ordine alfabetico Classifica per Contributo UE Espandi tutto Riduci tutto CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS Spagna Contributo UE Nessun dato Indirizzo Campus Cantoblanco, Universidad Autonoma 28049 MADRID Mostra sulla mappa Costo totale Nessun dato GBF - NATIONAL CENTRE FOR BIOTECHNOLOGY Germania Contributo UE Nessun dato Indirizzo Mascheroder Weg 1 38124 BRAUNSCHWEIG Mostra sulla mappa Costo totale Nessun dato Institute for Animal Health Regno Unito Contributo UE Nessun dato Indirizzo Compton Laboratory Compton RG16 0NN Newbury Mostra sulla mappa Costo totale Nessun dato
