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Hepatitis c virus (hcv) : prevention and treatment of infection and disease

Objective

The overall objective of this cluster is to contribute to the development of preventive and therapeutic vaccines against hepatitis C virus (HCV) infection. For this objective an in depth understanding of protective antiviral immune responses is essential by acquiring knowledge on mechanisms associated with HCV replication, assembly and fundamental knowledge on HCV specific immune responses in natural infections. A key element in the development of a vaccine is the choice of a delivery system capable to induce a humoral and/or a cellular-mediated protective immune response. The networks in this cluster proposal have strong, worldwide recognized expertise and have all parameters to monitor the planned analysis from fundamental in vitro studies to the evaluation of vaccine candidates in non-human primates. The basic strength of the Cluster is to re-unite expertise and unique systems that will allow a solid basis for the definition of clinical trials.

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

LEIDEN UNIVERSITY
Address
22,Albinusdreef 22 P4-25
2300 RC Leiden
Netherlands

Participants (15)

ALBERT-LUDWIGS-UNIVERSITAET FREIBURG
Germany
Address
Hugstetterstr. 55
79106 Freiburg (In Breisgau)
BERNA BIOTECH LTD
Switzerland
Address
Rehhagstrasse 79 A
3018 Bern
BIOMERIEUX ALLIANCE SA
France
Address
Chemin De L'orme
69280 Marcy-l'etoile
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
France
Address
7,Passage Du Vercors 7
69367 Lyon
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
France
Address
Rue Calmette 1
59021 Lille
FOUNDATION BIOMEDICAL PRIMATE RESEARCH CENTRE
Netherlands
Address
Lange Kleiweg 139
2288 GJ Rijswijk Zh
GSF-RESEARCH CENTER FOR ENVIRONMENT AND HEALTH
Germany
Address
Ingolstädter Landstrasse 1
81675 Muenchen
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France
Address
Cours Albert Thomas 151 Adr 5 - Rhône-alpes, Auve
69424 Lyon
JOHANNES GUTENBERG UNIVERSITAET MAINZ
Germany
Address
Obere Zahlbacher Strasse 67
55131 Mainz
KAROLINSKA INSTITUTE
Sweden
Address
Solnavagen 1
171 77 Stockholm
LUDWIG-MAXIMILIANS UNIVERSITY OF MUNICH
Germany
Address
Geschwister-scholl-platz 1
80539 Muenchen
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
United Kingdom
Address
John Radcliffe Hospital - Oxfordshire 5802
OX3 9DU Oxford/headington
UNIVERSIDAD DE NAVARRA
Spain
Address
Calle Irunlarrea 1
31080 Pamplona
UNIVERSITA DEGLI STUDI DI BARI
Italy
Address
Piazza Umberto I Palazzo Ateneo 1
70121 Bari
UNIVERSITE DE PARIS V 'RENÉ DESCARTES'
France
Address
156,Rue De Vaugirard 156, Chu Necker
75730 Paris