CORDIS
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Immunopathogenesis of respiratory syncytial virus infections in calves, mice, non-human primates, and humans : development of second generation subunit vaccines.

Project information

Grant agreement ID: QLK2-CT-1999-01044

  • Start date

    1 February 2000

  • End date

    31 January 2003

Funded under:

FP5-LIFE QUALITY

  • Overall budget:

    € 1 238 590

  • EU contribution

    € 983 653

Coordinated by:

ERASMUS UNIVERSITEIT ROTTERDAM

Netherlands

Objective

Infections with human and bovine RSV are major causes of severe respiratory disease. RSV vaccine development has been hampered by immuno pathological phenomena occurring during vaccine trials in infants in the 1960s with formalin-inactivated virus preparations (FI-RSV). Vaccination /challenge studies in rodents provided insight in possible underlying immunological mechanisms. Predisposition for enhanced pathology has also been demonstrated in calves and monkeys, but immune mechanistic studies have not been carried out. Here, we propose to identify immunological correlates of enhanced disease after FI-RSV vaccination in calves and mice (bRSV) and macaques (hRSV). Subsequently, we will evaluate three different non-replicating RSV vaccine candidates in these models, and in an established hRSV mouse model. In addition, we will study the RSV-specific immune response to one of these candidates in ongoing phase I/II human trials.

Coordinator

ERASMUS UNIVERSITEIT ROTTERDAM

Address

50,Dr. Molewaterplein 50 Erasmus University Hospital
3015 Ge Rotterdam

Netherlands

Participants (4)

AGRICULTURAL RESEARCH DEPARTMENT

Netherlands

GSF-RESEARCH CENTER FOR ENVIRONMENT AND HEALTH

Germany

IMPERIAL COLLEGE OF SCIENCE, TECHNOLOGY AND MEDICINE

United Kingdom

PIERRE FABRE MEDICAMENT S.A.

France

Project information

Grant agreement ID: QLK2-CT-1999-01044

  • Start date

    1 February 2000

  • End date

    31 January 2003

Funded under:

FP5-LIFE QUALITY

  • Overall budget:

    € 1 238 590

  • EU contribution

    € 983 653

Coordinated by:

ERASMUS UNIVERSITEIT ROTTERDAM

Netherlands