Cel The aim of this project is to generate a comprehensive platform of intellectual property to facilitate the discovery and development of a new generation of therapeutics with the ability to activate or inhibit the c-Ret receptor tyrosine kinase. Mutations in c-Ret are directly implicated in human cancers, and the c-Ret ligand, GDNF, is being developed as a therapeutic agent for neurodegenerative disorders such as Parkinson's disease and ALS. To develop c-Ret as a target for drug discovery we propose: i) to validate c-Ret as a drug target; ii) to develop scaleable assays for high throughput screening of c-Ret inhibitors and activators; iii) to isolate artificial c-Ret peptide ligands; iv) to determine the 3D structures of the extracellular and kinase domains of wild type and oncogenic c-Ret; v) to identify ligand binding sites in the c-Ret extracellular domain. Our long-term goal is to enter into license agreements with interested user groups for the exploitation of the generated knowledge and technology platform. Dziedzina nauki medical and health sciencesbasic medicinepharmacology and pharmacydrug discoverynatural sciencesbiological sciencesbiochemistrybiomoleculesnatural sciencesbiological sciencesgeneticsmutationmedical and health sciencesclinical medicineoncologymedical and health sciencesbasic medicineneurologyparkinson Program(-y) FP5-LIFE QUALITY - Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002 Temat(-y) 1.1.1.-3. - Key action The "Cell factory" Zaproszenie do składania wniosków Data not available System finansowania CSC - Cost-sharing contracts Koordynator KAROLINSKA INSTITUTE Wkład UE Brak danych Adres Retzius vaeg 8 171 77 STOCKHOLM Szwecja Zobacz na mapie Koszt całkowity Brak danych Uczestnicy (3) Sortuj alfabetycznie Sortuj według wkładu UE Rozwiń wszystko Zwiń wszystko AUGUST KIRCHENSTEIN INSTITUTE OF MICROBIOLOGY AND VIROLOGY Łotwa Wkład UE Brak danych Adres Ratsupites 1 1067 RIGA Zobacz na mapie Koszt całkowity Brak danych CANCER RESEARCH UK Zjednoczone Królestwo Wkład UE Brak danych Adres Lincoln's Inn Field 61 WC2A 3PX LONDON Zobacz na mapie Koszt całkowity Brak danych XERION PHARMACEUTICALS GMBH Niemcy Wkład UE Brak danych Adres Fraunhoferstrasse 9 82152 PLANEGG / KRAILLING Zobacz na mapie Koszt całkowity Brak danych
