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Development of high-throughput pna-based molecular diagnostic systems

Development of high-throughput pna-based molecular diagnostic systems

Objective

To improve gene mutation detection and screening in the clinical and research laboratories, the proposal aims at developing two fully automated molecular diagnostic systems based on high-throughput capillary electrophoresis (CE) and micro array biochips technology. These innovative systems will take advantage of:
(1) the use of peptide nucleic acid (PNA) probes in hybridisation reactions;
2) the implementation of a 96-capillary array electrophoresis device improved with novel CE coating and sieving matrices;
3) the building of an innovative automated micro array work- station with laser scanner and microscope-based imaging systems and software; and
4) the production of novel NIR-fluorescent dyes. These objectives will be achieved in combining the expertise, know-how, and resources of academic and industrial partners in a programmed fashion. This programme will result in the availability and, eventually, in the marketing of diagnostic systems that will make a measurable difference in research and clinical settings by delivering screening and diagnostic tests with high accuracy, reproducibility, reliability, and at a lower cost.

Coordinator

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE

Address

Rue De Tolbiac, 101
75654 Paris

France

Administrative Contact

Claude GRISCELLI (Prof.)

Participants (5)

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IMSTAR S.A.

France

INNOSENSE SRL

Italy

MAX-PLANCK-GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V.

Germany

MEDWAY SA

Switzerland

NATIONAL RESEARCH COUNCIL OF ITALY

Italy

Project information

Grant agreement ID: QLK3-CT-1999-00531

  • Start date

    1 February 2000

  • End date

    31 January 2003

Funded under:

FP5-LIFE QUALITY

  • Overall budget:

    € 2 615 466

  • EU contribution

    € 1 277 993

Coordinated by:

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE

France