In this application, for the first time, particulate matter (PM) will be collected from sites used in epidemiology (in addition to fresh diesel and gasoline PM) and extensively characterised physico-chemically prior to evaluation of bioactivity in in-vitro and in-vivo animals models. This unique approach will provide novel information of the oxidative and inflammatory reactivity of PM across Europe. Healthy controls, asthma and COPD patients are exposed to diesel, gasoline or selected ambient PM by inhalation/local bronchial instillation. Calculations of physico-chemical composition/source/ toxicity-health relationships thereby become feasible. The novel approach to link epidemology, toxicology and controlled human exposures will facilities a synergistic increase in the understanding of the adverse effects of PM. Moreover, it should help identify those components of PM which are of most importance for regulatory decision making within Europe.
Funding SchemeCSC - Cost-sharing contracts
WC2R 2LS London
3720 BA Bilthoven
EH1 1HN Edinburgh