Objective We have recently demonstrated that anti-idiotypic antibodies and peptides can mimic efficiently polysaccharide antigens and that protection through vaccination is possible. To extend this approach in order to obtain reagents with higher affinity and industrial utility we propose the following project. The main goal is the production of polypeptide structures which mimic polysaccharide epitome exploiting qualified knowledge in all known techniques for producing peptide- and antibody-based surrogate antigens. The three pathogens selected are appropriate for this aplication for distinct reasons:1) Brucella vaccination with whole S-LPS makes epidemiological control by serology impossible,2) Vibrio S-LPS exhibit poor immunogenicity and high crossreactivity,3) for S.pneumonie conjugate vaccines will not provide a complete solution for the problems with the current vaccine. Fields of science medical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsvaccinesnatural sciencesbiological sciencesbiochemistrybiomoleculescarbohydrates Programme(s) FP5-LIFE QUALITY - Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002 Topic(s) 1.1.1.-2. - Key action Control of Infectious Diseases Call for proposal Data not available Funding Scheme CSC - Cost-sharing contracts Coordinator UNIVERSITA' DEGLI STUDI DI SIENA EU contribution No data Address Via banchi di sotto 55 Siena Italy See on map Links Website Opens in new window Total cost No data Participants (6) Sort alphabetically Sort by EU Contribution Expand all Collapse all FACULTES UNIVERSITAIRES NOTRE-DAME DE LA PAIX DE NAMUR Belgium EU contribution No data Address Rue de bruxelles 61 5000 Namur / namen See on map Total cost No data INSTITUTE OF FOOD RESEARCH United Kingdom EU contribution No data Address Norwich research park, colney Norwich See on map Links Website Opens in new window Total cost No data KAROLINSKA INSTITUTE Sweden EU contribution No data Address Solnavagen 1 171 77 Stockholm See on map Total cost No data SWISS FEDERAL INSTITUTE OF TECHNOLOGY ZUERICH Switzerland EU contribution No data Address 101,raemistrasse 101, eth zentrum 8092 Zurich See on map Total cost No data UNIVERSITA DEGLI STUDI DI PERUGIA Italy EU contribution No data Address Piazza dell'universita, 1 06123 Perugia See on map Total cost No data UNIVERSITY OF LEICESTER United Kingdom EU contribution No data Address University road LE1 7RH Leicester See on map Links Website Opens in new window Total cost No data