Obiettivo We have recently demonstrated that anti-idiotypic antibodies and peptides can mimic efficiently polysaccharide antigens and that protection through vaccination is possible. To extend this approach in order to obtain reagents with higher affinity and industrial utility we propose the following project. The main goal is the production of polypeptide structures which mimic polysaccharide epitome exploiting qualified knowledge in all known techniques for producing peptide- and antibody-based surrogate antigens. The three pathogens selected are appropriate for this aplication for distinct reasons:1) Brucella vaccination with whole S-LPS makes epidemiological control by serology impossible,2) Vibrio S-LPS exhibit poor immunogenicity and high crossreactivity,3) for S.pneumonie conjugate vaccines will not provide a complete solution for the problems with the current vaccine. Campo scientifico medical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsvaccinesnatural sciencesbiological sciencesbiochemistrybiomoleculescarbohydrates Programma(i) FP5-LIFE QUALITY - Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002 Argomento(i) 1.1.1.-2. - Key action Control of Infectious Diseases Invito a presentare proposte Data not available Meccanismo di finanziamento CSC - Cost-sharing contracts Coordinatore UNIVERSITA' DEGLI STUDI DI SIENA Contributo UE Nessun dato Indirizzo Via banchi di sotto 55 Siena Italia Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato Partecipanti (6) Classifica in ordine alfabetico Classifica per Contributo UE Espandi tutto Riduci tutto FACULTES UNIVERSITAIRES NOTRE-DAME DE LA PAIX DE NAMUR Belgio Contributo UE Nessun dato Indirizzo Rue de bruxelles 61 5000 Namur / namen Mostra sulla mappa Costo totale Nessun dato INSTITUTE OF FOOD RESEARCH Regno Unito Contributo UE Nessun dato Indirizzo Norwich research park, colney Norwich Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato KAROLINSKA INSTITUTE Svezia Contributo UE Nessun dato Indirizzo Solnavagen 1 171 77 Stockholm Mostra sulla mappa Costo totale Nessun dato SWISS FEDERAL INSTITUTE OF TECHNOLOGY ZUERICH Svizzera Contributo UE Nessun dato Indirizzo 101,raemistrasse 101, eth zentrum 8092 Zurich Mostra sulla mappa Costo totale Nessun dato UNIVERSITA DEGLI STUDI DI PERUGIA Italia Contributo UE Nessun dato Indirizzo Piazza dell'universita, 1 06123 Perugia Mostra sulla mappa Costo totale Nessun dato UNIVERSITY OF LEICESTER Regno Unito Contributo UE Nessun dato Indirizzo University road LE1 7RH Leicester Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato