Objective This is a research and development project, describing a new biotechnology approach to cell replacement therapy for a number of severe diseases, based on genetically modified mesoderm stem cells.The research will cover all aspects of the problem, including:1) isolation of stem cells from different tissues and organs,2) study of their phenotype and basis biology,3) design and construction of viral vectors for their genetic modification,4) development of pre-clinical models of disease correction by genetically-modified stem cell transplantation, and5) products and protocols for phase I/II clinical application.The research will be carried out by a partnership of six laboratories in four different European countries, which include a start-up biotechnology company with a strategic interest in tissue engineering and gene therapy. The groups are led by top European scientists who pioneered the field and have the highest qualification. Fields of science medical and health sciencesmedical biotechnologygenetic engineeringgene therapymedical and health sciencesmedical biotechnologytissue engineeringmedical and health sciencesmedical biotechnologycells technologiesstem cellsmedical and health sciencesclinical medicinetransplantation Programme(s) FP5-LIFE QUALITY - Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002 Topic(s) 1.1.1.-3. - Key action The "Cell factory" Call for proposal Data not available Funding Scheme CSC - Cost-sharing contracts Coordinator UNIVERSITY OF ROME "LA SAPIENZA" EU contribution No data Address Piazzale Aldo Moro 5 00185 ROMA Italy See on map Total cost No data Participants (5) Sort alphabetically Sort by EU Contribution Expand all Collapse all ERASMUS UNIVERSITEIT ROTTERDAM Netherlands EU contribution No data Address BURGEMEESTER OUDLAAN 50 1738 ROTTERDAM See on map Links Website Opens in new window Total cost No data GENERA SPA Italy EU contribution No data Address Via Olgettina 58 20132 MILANO See on map Total cost No data INSTITUT PASTEUR France EU contribution No data Address Rue du Docteur Roux 25 75724 PARIS See on map Total cost No data MARIO NEGRI INSTITUTE FOR PHARMACOLOGICAL RESEARCH Italy EU contribution No data Address Via Eritrea 62 20157 MILANO See on map Links Website Opens in new window Total cost No data Medical Research Council (MRC) United Kingdom EU contribution No data Address 20 Park Crescent W1N 4AL London See on map Total cost No data
