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Development of a cancer vaccine combining dna and specific glycoprotein/glycopeptide formulations of a tumour antigen

Development of a cancer vaccine combining dna and specific glycoprotein/glycopeptide formulations of a tumour antigen

Objective

This innovative project will develop diagnostic kits using synthetic peptide Ags to detect Abs to post-translational proteins also preceding disorder symptoms not yet identified (via MOG model protein). Characterisation of native glycosylation will contribute to discover influence in Ab recognition. Molecular modelling will de- sign the best synthetic Ags for T- and B-cell response in animal models and patients affected by autoimmune diseases of nervous system (i.e., MS). These Ags will be used in a kit detecting anti-MOG Abs. A vital contribution to social objectives and to improvement of quality of life comes from a correlation study of Ab titre vs. MRI. Validation/ exploitation of a very cheap kit (compared to current costs) will be done in Clinical Units involving patients (final users). A strategic impact surrogate marker for the follow-up of disease activity will be developed only thanks to critical mass of balanced multidisciplinary competence and to dissemination of the results.

Coordinator

CANCER RESEARCH UK

Address

Lincoln'S Inn Field 61
Wc2a 3px London

United Kingdom

Administrative Contact

Judith MARSDEN (Ms)

Participants (8)

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FORSCHUNGSZENTRUM JUELICH GMBH

Germany

GOETEBORG UNIVERSITY

Sweden

TRANSGENE SA

France

UNIVERSITY OF COPENHAGEN

Denmark

UNIVERSITY OF HAMBURG

Germany

UNIVERSITY OF ROME "LA SAPIENZA"

Italy

UNIVERSITY OF UMEAA

Sweden

UNIVERSITY OF ZURICH

Switzerland

Project information

Grant agreement ID: QLK3-CT-1999-00217

  • Start date

    1 January 2000

  • End date

    31 December 2002

Funded under:

FP5-LIFE QUALITY

  • Overall budget:

    € 2 616 444

  • EU contribution

    € 1 926 405

Coordinated by:

CANCER RESEARCH UK

United Kingdom