Objetivo Lymphatic collecting ducts are thin walled valved vessels which contract spontaneously and propel lymph by means of these regular well coordinated contractions. They have a sympathetic noradrenergic innervation stimulation of which increases their frequency of contraction and thus increases lymph flow. In addition to the alpha receptors which mediate this excitatory response, lymphatic smooth muscle also has beta receptors, stimulation of which inhibits flow by decreasing the frequency and force of spontaneous contractions. This project seeks to make the first detailed study of the mechanism of these responses. The expertise of three European laboratories will be combined to apply modern biophysical and biochemical techniques to elucidate: the properties and distribution of the membrane receptors; the nature of the coupling of these to intracellular second messengers and; the way in which the latter mediators affect the vessel's electrical and mechanical responses. The results should be invaluable in furthering our understanding of this very important but little understood circulation and for providing a rational basis for the design of drugs to drugs to control the lymph pump. Programa(s) FP2-SCIENCE - Programme plan (EEC) to stimulate the international cooperation and interchange needed by European research scientists (SCIENCE), 1988-1992 Tema(s) Data not available Convocatoria de propuestas Data not available Régimen de financiación CSC - Cost-sharing contracts Coordinador Queen's University of Belfast Aportación de la UE Sin datos Dirección 97 Lisburn Road BT9 7BL Belfast Reino Unido Ver en el mapa Coste total Sin datos Participantes (2) Ordenar alfabéticamente Ordenar por aportación de la UE Ampliar todo Contraer todo Stiftung Deutsches Krebsforschungszentrum Alemania Aportación de la UE Sin datos Dirección Im Neuenheimer Feld 280 69120 Heidelberg Ver en el mapa Coste total Sin datos University College Dublin Irlanda Aportación de la UE Sin datos Dirección Fosters Avenue Blackrock 4 Dublin Ver en el mapa Coste total Sin datos
