Skip to main content

Cord blood as an allogeneic source of stem cell for clinical use

Objective


Cord blood cells, collected at birth, have new interesting properties which can be used for treatment of leukemias and other malignant diseases and also for the treatment of genetic or acquired hematological disorders. Cord blood banks have been established worldwide, and thanks to international collaboration, results of allogeneic unrelated cord blood transplants have been analysed. From these studies, it can be concluded that this new source of hematopoietic stem cells is a life-saving therapy used in a large variety of potentially fatal diseases mostly in children. The objectives of this proposal are to better characterise hematopoietic stem cells present in cord blood and take advantage of the immaturity and proliferative characteristics of the cells to treat a large variety of malignant, immunological, genetic and infectious diseases. The proposal will be divided in 4 components: hematopoiesis, immunology, clinical applications of cord blood cells and interface between transplant centres and cord blood banks.

Funding Scheme

THN - Thematic network contracts

Coordinator

ASSOCIATION POUR LA RECHERCHE SUR LES TRANSPLANTATIONS MEDULLAIRES
Address
Avenue Claude Vellefaux 1
75475 Paris
France

Participants (10)

ACADEMISCH ZIEKENHUIS LEIDEN
Netherlands
Address
Albinusdreef 2
2300RC Leiden
CANCER RESEARCH INSTITUTE
Spain
Address
Autovia Castelldefels Km 2,7
08907 Hospitalet Del Llobregat
FONDAZIONE II SANGUE
Italy
Address
Via Francesco Sforza, 35
20122 Milano
HEINRICH-HEINE-UNIVERSITAET DUESSELDORF
Germany
Address
Moorenstrasse, 5 Bldg 14.80
40225 Duesseldorf
HLA ET MÉDECINE
France
Address
15,Rue De L'ecole De Médecine 15
75006 Paris
HOSPITAL UNIVERSITARIO CLINICA PUERTA DE HIERRO
Spain
Address
San Martin De Porres 4
28035 Madrid
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France
Address
12, Avenue Paul Vaillant Couturier
94807 Villejuif
IRCCS POLICLINICO SAN MATTEO - ISTITUTO DI RICOVERO E CURA A CARATTERE SCIENTIFICO
Italy
Address
P. Le Golgi 2
27100 Pavia
THE ANTHONY NOLAN BONE MARROW TRUST
United Kingdom
Address
Pond Street, Royal Free Hospital
NW3 2QG London
UNIVERSITY OF ROME "LA SAPIENZA"
Italy
Address
Viale Benevento
00161 Roma