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Development of recombinant bcg multivaccines and complementary diagnostics for predominant parasitic and epizootic diseases of ruminants in latin america

Project information

Grant agreement ID: ICA4-CT-2000-30032

  • Start date

    1 October 2000

  • End date

    30 September 2005

Funded under:

FP5-INCO 2

  • Overall budget:

    € 959 909

  • EU contribution

    € 959 909

Coordinated by:

UNIVERSITY OF SURREY

United Kingdom

Objective

Infectious diseases are a major burden on agriculture in developing counties. Current vaccines are expensive and often ineffective. We aim to develop a live recombinant BCG (brig) multivaccine that protects against predominant ruminant parasitic diseases in Latin America. Vector/host system will be developed to deliver parasite antigens to the bovine immune system. Immunogenicity will be measured in mice and protective efficacy measured in cattle. The brig vaccine will be developed in a strain deleted for dominant antigens. In parallel, animmunodiagnostic will be developed that targets deleted antigens and thereby distinguishes brig vaccination from natural Mycobacterium bovid infection. A rBCG vaccine and compatible TB diagnostic will promote affordable control of ruminant disease in developing counties. The vaccine should be cheap, heat-stable and effective via a single inoculation, and thereby promote sustainable development.

Leaflet | Map data © OpenStreetMap contributors, Credit: EC-GISCO, © EuroGeographics for the administrative boundaries

Coordinator

UNIVERSITY OF SURREY

Address

United Kingdom

Participants (5)

FUNDACAO OSWALDO CRUZ - MINISTERIO DA SAUDE

Brazil

INSTITUT PASTEUR

France

NATIONAL INSTITUTE OF AGRICULTURAL RESEARCH

Argentina

NATIONAL UNIVERSITY OF IRELAND, GALWAY

Ireland

UNIVERSIDADE FEDERAL DE PELOTAS

Brazil

Project information

Grant agreement ID: ICA4-CT-2000-30032

  • Start date

    1 October 2000

  • End date

    30 September 2005

Funded under:

FP5-INCO 2

  • Overall budget:

    € 959 909

  • EU contribution

    € 959 909

Coordinated by:

UNIVERSITY OF SURREY

United Kingdom

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