Objectif The age-related decline in endocrine function plays an important role in many of the changes in body composition and brain function that form part of the aging process. We propose to carry out studies in animals investigating how synthetic growth hormone secretagogues (GHS) act to improve body composition and brain function. Electrophysiological and neuroanatomical studies will determine how GHS interact with the brain pathways controlling growth hormone secretion, appetite and metabolism. Chronic GHS exposure will result in a new equilibrium of endocrine and CNS activity - we will study the consequences of long-term GHS exposure on hypothalamic gene expression and body composition. Studies of GHS action in animals with deletions in specific genes will identify the key sites of action of these compounds. Studies in obese diabetic animals (i.e. with symptoms of syndrome X) will include effects of GHS agonists and antagonists on the progression of the disease. Finally, since GHS increase circulating levels of insulin-like growth factors, we will determine the effects of GHS in the central IGF system, that has a protective role against neurodegeneration Champ scientifique natural sciencesbiological sciencesneurobiology Programme(s) FP5-LIFE QUALITY - Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002 Thème(s) 1.1.1.-6. - Key action The Ageing Population and Disabilities Appel à propositions Data not available Régime de financement CSC - Cost-sharing contracts Coordinateur THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE Contribution de l’UE Aucune donnée Adresse Downing Street CB2 3EG Cambridge Royaume-Uni Voir sur la carte Coût total Aucune donnée Participants (4) Trier par ordre alphabétique Trier par contribution de l’UE Tout développer Tout réduire GOETEBORG UNIVERSITY Suède Contribution de l’UE Aucune donnée Adresse Vasaparken 405 30 GOETEBORG Voir sur la carte Coût total Aucune donnée HOSPITAL NINO JESUS Espagne Contribution de l’UE Aucune donnée Adresse Menendez Pelayo 65 28009 MADRID Voir sur la carte Coût total Aucune donnée NOVO-NORDISK A/S Danemark Contribution de l’UE Aucune donnée Adresse 1,Novo allT, 6B3 2880 BAGSVAERD Voir sur la carte Coût total Aucune donnée UNIVERSITY OF EDINBURGH Royaume-Uni Contribution de l’UE Aucune donnée Adresse Mayfield Road EH9 3JU EDINBURGH Voir sur la carte Coût total Aucune donnée