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Age-related changes in learning and memory: neural cell adhesion molecules, associated carbohydrates and ligands

Age-related changes in learning and memory: neural cell adhesion molecules, associated carbohydrates and ligands

Objective

The aim of our joint study is to investigate the roles of the neural cell adhesion molecules, NCAM and L1, in aged rodents with regard to the efficacy of acquisition, retention and recall of learned tasks versus that in young and adult animals. We wish to examine the contribution of the two molecules to synaptic plasticity using LTP in vitro and learning paradigms in vivo in wild type and transgenic animals. We also wish to characterise the functional properties of sub domain fragments of these molecules including their cognate legends and carbohydrates in modifying learning and memory. Further, we wish to identify novel legends of NCAM and L1 by means of rational design and combinatorial chemistry and to evaluate of such legends to preserve and promote the capacity for learning at old age and under stress.

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Coordinator

N/A

Address

Administrative Contact

Jüergen DRALLE (Dr.)

Participants (5)

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CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE

France

NATIONAL UNIVERSITY OF IRELAND, DUBLIN

Ireland

SCHAFER-N

Denmark

UNIVERSIDAD NACIONAL DE EDUCACION A DISTANCIA

Spain

UNIVERSITY OF COPENHAGEN

Denmark

Project information

Grant agreement ID: QLK6-CT-1999-02187

  • Start date

    1 January 2000

  • End date

    31 December 2002

Funded under:

FP5-LIFE QUALITY

  • Overall budget:

    € 1 954 031

  • EU contribution

    € 1 536 763

Coordinated by:

N/A