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Genomic instability and radiation-induced cancer

Objective

The recent discovery of radiation-induced genomic instability has raised concern for its implication in the radiation protection of the public, especially, quantification of human risk for low doses and high LET exposure. The role of radiation-induced genomic instability in radiation carcinogenesis will be studied with animal models and mechanistic investigations of induction and transmission. Genes and genome regions involved will be studied and the basis of individual susceptibility investigated. The relationship of genomic instability endpoints to radiation dose, dose rate and quality will be determined. The proposal brings together all major European laboratories involved in the discovery, characterization and mechanistic investigation of radiation-induced genomic instability. A state of the art working document on the relevance of genomic instability for cancer risk assessment will be prepared for the use of European decision makers.

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

RADIATION AND NUCLEAR SAFETY AUTHORITY
Address
4,Laippatie 4
00881 Helsinki
Finland

Participants (8)

COMMISSARIAT A L'ENERGIE ATOMIQUE
France
Address
Avenue Du General Leclerc 60-68
92265 Fontenay Aux Roses
DUBLIN INSTITUTE OF TECHNOLOGY
Ireland
Address
40-41,Kevin Street 40-41 Moravian Church
8 Dublin
GRAY LABORATORY CANCER RESEARCH TRUST
United Kingdom
Address
Mount Vernon Hospital
HA6 2JR Northwood
GSF-RESEARCH CENTER FOR ENVIRONMENT AND HEALTH
Germany
Address
Ingolstaedter Landstrasse 1
85764 Oberschleissheim
KAROLINSKA INSTITUTE
Sweden
Address
Haelsvaegen 7
141 57 Huddinge
MEDICAL RESEARCH COUNCIL
United Kingdom
Address
Harwell
OX11 0RD Didcot
UNIVERSITY OF DUNDEE
United Kingdom
Address

DD1 9SY Dundee
University of Cambridge
United Kingdom
Address
Downing Street
CB2 3DY Cambridge