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Chernobyl, an integrated pan-European study : morphology, oncogenes, DNA repair and outcome in radiation carcinogenesis

Chernobyl, an integrated pan-European study : morphology, oncogenes, DNA repair and outcome in radiation carcinogenesis

Objective

To advance our understanding of radiation carcinogenesis and to obtain information relevant to radiation protection and the management of patients with radiation induced thyroid tumours we propose to carry out an integrated study of morphological, cell and molecular biological and clinical aspects of thyroid tumours from patients exposed to high levels of fallout from the Chernobyl accident. We will utilise the unique resource of paired tumour/normal tissue samples from these patients, carry out the study in leading European centres, using novel techniques of cell cycle analysis, DNA chip technology, FISH and analysis of DNA repair mechanisms. These studies will be carried out on the same tumours and the results will be correlated with careful diagnosis, morphological analysis of the tumour samples and evidence of clinical outcome to provide a comprehensive study of the defects involved in radiation carcinogenesis and their relevance to diagnosis and tumour behaviour.
181 cases studied, morphological data completed on all and molecular biological data on ret completed on 162 assayable cases. RFG and mutant protein studies nearing completion. Microarray analysis completed on a subset of tumours - no differences observed between post Chernobyl cancers and those of non radiation aetiology. Rearrangements identified by FISH and correlated with RT-PCR data. Database complete and ready to undergo analysis for correlation with morphology and clinical presentation. Large dataset ready for transfer to the Chernobyl Tissue Bank for integration with other projects. 13 papers published, submitted or in press - more in preparation.
Leaflet | Map data © OpenStreetMap contributors, Credit: EC-GISCO, © EuroGeographics for the administrative boundaries

Coordinator

UNIVERSITY OF WALES SWANSEA

Address

Singleton Park
Sa2 8pp Swansea

United Kingdom

Participants (5)

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GSF-RESEARCH CENTER FOR ENVIRONMENT AND HEALTH

Germany

INSTITUTE OF ENDOCRINOLOGY AND METABOLISM - ACADEMY OF MEDICAL SCIENCES OF THE UKRAINE

Ukraine

UNIVERSITA DEGLI STUDI DI NAPOLI FEDERICO II

Italy

UNIVERSITE LIBRE DE BRUXELLES

Belgium

University of Cambridge

United Kingdom

Project information

Grant agreement ID: FIGH-CT-1999-00004

  • Start date

    1 March 2000

  • End date

    31 August 2003

Funded under:

FP5-EAECTP C

  • Overall budget:

    € 1 235 315

  • EU contribution

    € 896 963

Coordinated by:

UNIVERSITY OF WALES SWANSEA

United Kingdom