Objectif To advance our understanding of radiation carcinogenesis and to obtain information relevant to radiation protection and the management of patients with radiation induced thyroid tumours we propose to carry out an integrated study of morphological, cell and molecular biological and clinical aspects of thyroid tumours from patients exposed to high levels of fallout from the Chernobyl accident. We will utilise the unique resource of paired tumour/normal tissue samples from these patients, carry out the study in leading European centres, using novel techniques of cell cycle analysis, DNA chip technology, FISH and analysis of DNA repair mechanisms. These studies will be carried out on the same tumours and the results will be correlated with careful diagnosis, morphological analysis of the tumour samples and evidence of clinical outcome to provide a comprehensive study of the defects involved in radiation carcinogenesis and their relevance to diagnosis and tumour behaviour.181 cases studied, morphological data completed on all and molecular biological data on ret completed on 162 assayable cases. RFG and mutant protein studies nearing completion. Microarray analysis completed on a subset of tumours - no differences observed between post Chernobyl cancers and those of non radiation aetiology. Rearrangements identified by FISH and correlated with RT-PCR data. Database complete and ready to undergo analysis for correlation with morphology and clinical presentation. Large dataset ready for transfer to the Chernobyl Tissue Bank for integration with other projects. 13 papers published, submitted or in press - more in preparation. Champ scientifique natural sciencescomputer and information sciencesdatabasesnatural sciencesbiological sciencesgeneticsDNAnatural sciencesbiological sciencesbiochemistrybiomoleculesproteinsmedical and health sciencesclinical medicineoncology Programme(s) FP5-EAECTP C - Research and training programme (Euratom) in the field of nuclear energy (1998 to 2002) Thème(s) 2.1.3.-1.1. - Risk estimates for exposures at low dose and low dose rate Appel à propositions Data not available Régime de financement CSC - Cost-sharing contracts Coordinateur UNIVERSITY OF WALES SWANSEA Contribution de l’UE Aucune donnée Adresse Singleton Park SA2 8PP SWANSEA Royaume-Uni Voir sur la carte Coût total Aucune donnée Participants (5) Trier par ordre alphabétique Trier par contribution de l’UE Tout développer Tout réduire GSF-RESEARCH CENTER FOR ENVIRONMENT AND HEALTH Allemagne Contribution de l’UE Aucune donnée Adresse Ingolstädter Landstrasse 1 85764 Neuherberg Voir sur la carte Coût total Aucune donnée INSTITUTE OF ENDOCRINOLOGY AND METABOLISM - ACADEMY OF MEDICAL SCIENCES OF THE UKRAINE Ukraine Contribution de l’UE Aucune donnée Adresse 69,Vyshgorodskaya Street 69 254114 KIEV Voir sur la carte Coût total Aucune donnée UNIVERSITA DEGLI STUDI DI NAPOLI FEDERICO II Italie Contribution de l’UE Aucune donnée Adresse Via Sergio Pansini 5 80131 NAPOLI Voir sur la carte Coût total Aucune donnée UNIVERSITE LIBRE DE BRUXELLES Belgique Contribution de l’UE Aucune donnée Adresse 808,Route de Lennik 808 Campus Erasme - Building C 1070 BRUXELLES Voir sur la carte Coût total Aucune donnée University of Cambridge Royaume-Uni Contribution de l’UE Aucune donnée Adresse Tennis Court Road CB2 1QP Cambridge Voir sur la carte Coût total Aucune donnée
