CORDIS
EU research results

CORDIS

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Improved cancer risk quantification for environmental, medical and occupational exposures to low doses of ionising radiation by mechanistic models

Project information

Grant agreement ID: FIGH-CT-1999-00005

  • Start date

    1 February 2000

  • End date

    31 January 2003

Funded under:

FP5-EAECTP C

  • Overall budget:

    € 2 503 213

  • EU contribution

    € 1 100 011

Coordinated by:

GSF-RESEARCH CENTER FOR ENVIRONMENT AND HEALTH

Germany

Objective

This project will contribute to the solution of the important open problem of quantification of stomatic radiation risks to humans at low doses (below, say, 10 mSv) and low dose rates of ionising radiation of various qualities at least for the organs lung, thyroid and bone. Since this problem cannot be solved by basic biological investigations nor by epidemiological studies alone, the scientific knowledge from both areas will be combined to develop and test quantitative mechanistic models for the dose-time-effect surfaces of radiation carcinogenesis in these organs. Existing data and theories are evaluated and used for the modelling of radiation transport and interaction, for the modelling of subsequent damage and repair of DNA, genes, cells and organs taking normal oxidative damage into account, and for the multi-step modelling of carcinogenesis. Conclusions will be drawn for the general radiation of the worker and the public.

Coordinator

GSF-RESEARCH CENTER FOR ENVIRONMENT AND HEALTH

Address

Ingolstaedter Landstrasse 1
85764 Oberschleissheim

Germany

Participants (8)

ASSOCIATION POUR LE DEVELOPPEMENT DE LA PHYSIQUE ATOMIQUE

France

GERMAN CANCER RESEARCH CENTER

Germany

MEDICAL RESEARCH COUNCIL

United Kingdom

NATIONAL INSTITUTE OF PUBLIC HEALTH AND ENVIRONMENT

Netherlands

NATIONAL RADIOLOGICAL PROTECTION BOARD

United Kingdom

PAUL SCHERRER INSTITUT

Switzerland

THE UNIVERSITY OF MILANO

Italy

UNIVERSITY OF SALZBURG

Austria

Project information

Grant agreement ID: FIGH-CT-1999-00005

  • Start date

    1 February 2000

  • End date

    31 January 2003

Funded under:

FP5-EAECTP C

  • Overall budget:

    € 2 503 213

  • EU contribution

    € 1 100 011

Coordinated by:

GSF-RESEARCH CENTER FOR ENVIRONMENT AND HEALTH

Germany