Skip to main content

DNA damage response mechanisms in radiation protection

Objective

A detailed knowledge of basic mechanisms by which ionizing radiation induces cancer and genetic disorders is essential for informed judgements to be made in radiation protection. The identification of most of the genes involved in the DNA damage responses to radiation and the generation of knockout mice defective in these processes provide the basis for further improvement of our understanding of the mechanisms of the different DNA damage response pathways and their interactions. To achieve these goals we will exploit new technologies and utilise different organisms. To understand the consequences of deficiencies in radiation responses in man we will analyse the defects in damage response mechanisms in rare radiosensitive individuals. The tools and concepts that we will develop will assist in the understanding of genetic changes and radiation carcinogenesis in man and will ultimately help to extrapolate to the effects of low doses and low dose-rates.

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

LEIDEN UNIVERSITY
Address
Wassenaarseweg 72
2300 RA Leiden
Netherlands

Participants (6)

ERASMUS UNIVERSITEIT ROTTERDAM
Netherlands
Address
Dr. Molewaterplein 50
3000 DR Rotterdam
GSF-RESEARCH CENTER FOR ENVIRONMENT AND HEALTH
Germany
Address
Ingolstädter Landstrasse 1
85764 Neuherberg
INSTITUT CURIE
France
Address
Rue D'ulm 26
75248 Paris
MEDICAL RESEARCH COUNCIL
United Kingdom
Address
Sussex University
BN1 9RR Falmer, Brighton
MEDICAL RESEARCH COUNCIL
United Kingdom
Address
Harwell
OX11 0RD Didcot
UNIVERSITY OF SUSSEX
United Kingdom
Address
Falmer
BN1 9RR Brighton / Falmer