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Interruption of malaria transmission : vaccine strategies

Project information

Grant agreement ID: QLK2-CT-1999-00753

  • Start date

    1 March 2000

  • End date

    31 December 2003

Funded under:

FP5-LIFE QUALITY

  • Overall budget:

    € 2 694 815

  • EU contribution

    € 2 499 962

Coordinated by:

STICHTING KATHOLIEKE UNIVERSITEIT

Netherlands

Objective

Malaria is a major infectious disease in the world with tremendous impact on quality of life. Malaria control is difficult and the available tools are limited. Vaccines will be the only long-term and cost-effective tools to control this ever-growing problem. Malaria is transmitted by sexual stages of Plasmodium falciparum. Sexual stage malaria vaccines aim at an arrest of the transmission and therefore spread or (re)-introduction of malaria in a risk area. The objectives are focussed on production and development of a transmission-blocking (TB)-vaccine. The objectives and expected outcome include
1) production of a TBPfs48/45 peptide vaccine up to the phase of clinical testing
2) identification of novel parasite antigens on gametocyte-infected red blood cells, gametes/kookiness and mosquitoes.
3) improvement of (bio)-assays for TB-immunity by the use of quantitative molecular techniques and development of immune correlates of protection.
4) Application of (new) animal models (marine, non-human primates) to be used in studies on biological function with genetically modified parasites and for pre-screening for human trials.

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Coordinator

STICHTING KATHOLIEKE UNIVERSITEIT

Address

22,Geert Grooteplein Zuid 22
6500 Hb Nijmegen

Netherlands

Participants (8)

FOUNDATION BIOMEDICAL PRIMATE RESEARCH CENTRE

Netherlands

IMPERIAL COLLEGE OF SCIENCE, TECHNOLOGY AND MEDICINE

United Kingdom

LEIDEN UNIVERSITY

Netherlands

LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE

THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD

United Kingdom

UNIVERSIDADE NOVA DE LISBOA

Portugal

UNIVERSITY OF GLASGOW

United Kingdom

University of Aberdeen

United Kingdom

Project information

Grant agreement ID: QLK2-CT-1999-00753

  • Start date

    1 March 2000

  • End date

    31 December 2003

Funded under:

FP5-LIFE QUALITY

  • Overall budget:

    € 2 694 815

  • EU contribution

    € 2 499 962

Coordinated by:

STICHTING KATHOLIEKE UNIVERSITEIT

Netherlands