Obiettivo The purpose of the research is to elucidate immune mechanisms and specificities that correlate with parasitological protection in three complementary systems: i) the target system of Onchocerca ovules in humans ii) the closely analogous system of Onchocerca change in cattle (which permits experimental manipulation in laboratory and field settings); iii) in the mouse model of Litosomoides sigmodontis (which permits detailed immunological analysis in a host supporting complete development of a filarial nematode.) In combination, these systems allow us to address the basis of naturally acquired immunity (against developing larvae and/or microfilariae) through immunoepidemiological and case-controlled comparisons (using defined antigens and parasite extracts); the basis of vaccine-induced immunity (using defined antigens and irradiated larvae); the impact of chemotherapy (both adulticides and microfilaricides ) on protection; and the effects of immunomodulation mediated by chronic infection. Campo scientifico agricultural sciencesanimal and dairy sciencedomestic animalsanimal husbandry Programma(i) FP5-INCO 2 - Programme for research, technological development and demonstration on "Confirming the international role of Community research,1998-2002" Argomento(i) Data not available Invito a presentare proposte Data not available Meccanismo di finanziamento CSC - Cost-sharing contracts Coordinatore UNIVERSITY OF EDINBURGH Contributo UE Nessun dato Indirizzo Easter Bush Sir Alexander Robertson Building EH25 9RG ROSLIN Regno Unito Mostra sulla mappa Costo totale Nessun dato Partecipanti (7) Classifica in ordine alfabetico Classifica per Contributo UE Espandi tutto Riduci tutto BERNHARD NOCHT INSTITUT FUER TROPENMEDIZIN Germania Contributo UE Nessun dato Indirizzo Bernhard-Nocht-Straße 74 20359 HAMBURG Mostra sulla mappa Costo totale Nessun dato INSTITUTE OF AGRICULTURAL RESEARCH FOR DEVELOPMENT Camerun Contributo UE Nessun dato Indirizzo Ngaoundere N'GAOUNDERE Mostra sulla mappa Costo totale Nessun dato LIVERPOOL SCHOOL OF TROPICAL MEDICINE Regno Unito Contributo UE Nessun dato Indirizzo Pembroke Place LIVERPOOL Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato MUSEUM NATIONAL D'HISTOIRE NATURELLE Francia Contributo UE Nessun dato Indirizzo Rue Buffon 61 75231 PARIS Mostra sulla mappa Costo totale Nessun dato THE UNIVERSITY OF TUEBINGEN Germania Contributo UE Nessun dato Indirizzo 27,Wilhelmstrasse 27 72074 TUEBINGEN Mostra sulla mappa Costo totale Nessun dato UNIVERSITY OF BUEA Camerun Contributo UE Nessun dato Indirizzo 20 BUEA Mostra sulla mappa Costo totale Nessun dato UNIVERSITY OF SCIENCE AND TECHNOLOGY, KUMASI Ghana Contributo UE Nessun dato Indirizzo University Post Office KUMASI Mostra sulla mappa Costo totale Nessun dato
