Obiettivo Milk protein peptides can inhibit angiotensin-I-converting enzyme (ACE) Drugs, which inhibit ACE, are in widespread use in cardiovascular medicine. Little or no information is available on the physiological efficacy in man of ingesting natural milk protein peptides/hydrolysis's, which inhibit ACE in vitro. Therefore, it is proposed to address this European-wide functional food ingredient problem/opportunity. The proposal objectives are to perform a detailed physiological, physicochemical, immunochemical and catechetical characterisation, in addition to a consumer assessment of these naturally derived inhibitors of ACE. Milk proteins will be hydrolysed using food-grade proteases. Clinical/bio availability trials will be performed in human volunteers. Immunochemical studies will use serum samples from humans fed ACE inhibitory hydrolysis. Catechetical studies will use human cell culture systems. Consumer awareness will be assessed on a global basis. The outcome of this proposal should lead to the development of clinically validated health claims in respect to the physiological efficiency and safety of ingesting milk protein-derived inhibitors of ACE. Campo scientifico natural sciencesbiological sciencesbiochemistrybiomoleculesproteinsenzymes Programma(i) FP5-LIFE QUALITY - Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002 Argomento(i) 1.1.1.-1. - Key action Food, Nutrition and Health Invito a presentare proposte Data not available Meccanismo di finanziamento CSC - Cost-sharing contracts Coordinatore UNIVERSITY OF LIMERICK Contributo UE Nessun dato Indirizzo Plassey Technological Park 61 LIMERICK Irlanda Mostra sulla mappa Costo totale Nessun dato Partecipanti (3) Classifica in ordine alfabetico Classifica per Contributo UE Espandi tutto Riduci tutto FEDERAL RESEARCH CENTRE FOR NUTRITION AND FOOD Germania Contributo UE Nessun dato Indirizzo Hermann Weigmann Straße 1 24103 KIEL Mostra sulla mappa Costo totale Nessun dato GLANBIA INGREDIENTS (BALLYRAGGET) LTD Irlanda Contributo UE Nessun dato Indirizzo Ballyragget Co. Kilkenny Mostra sulla mappa Costo totale Nessun dato UNIVERSITY OF DUNDEE Regno Unito Contributo UE Nessun dato Indirizzo Ninewells hospital and Medical School DD1 9SY DUNDEE Mostra sulla mappa Costo totale Nessun dato
