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Cellular production of human recombinant collagens, gelatins, laminins and growth factors and their use in vascular grafts and other applications

Cellular production of human recombinant collagens, gelatins, laminins and growth factors and their use in vascular grafts and other applications

Objective

Collagens and laminas have crucial roles in the extra cellular matrix. Collagens have many applications in medicine, cosmetics and commodity products. Collagens presently used for such applications are derived from animal tissues. We will develop efficient recombinant production applicable to any given collagen type, and test the efficacy of the produced human collagens in several applications. We will also develop man-made basement membranes composed of suitable combinations of collagens; laminas and growth regulators endogenously present in these therapeutically important specialized matrices, and test their use in improving the endothelialization of vascular grafts. Furthermore, we will develop recombinant production of gelatine used in numerous applications.

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Coordinator

UNIVERSITY OF OULU

Address

Pentti Kaiterankatu 1
90014 Oulu

Finland

Administrative Contact

Hannu PIETILA (Mr)

Participants (5)

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CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE

France

FIBROGEN EUROPE OY

Finland

KAROLINSKA INSTITUTE

Sweden

MAX-PLANCK-GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V.

Germany

UNIVERSITY OF HELSINKI

Finland

Project information

Grant agreement ID: QLK3-CT-2000-00084

  • Start date

    1 January 2001

  • End date

    30 June 2004

Funded under:

FP5-LIFE QUALITY

  • Overall budget:

    € 2 464 350

  • EU contribution

    € 1 787 281

Coordinated by:

UNIVERSITY OF OULU

Finland