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Towards new antibiotics

Project information

Grant agreement ID: QLK3-CT-2000-00513

  • Start date

    1 January 2001

  • End date

    31 December 2003

Funded under:

FP5-LIFE QUALITY

  • Overall budget:

    € 1 532 401

  • EU contribution

    € 1 366 200

Coordinated by:

THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD

United Kingdom

Objective

This project will produce Cell Factories (CAS) for the clean synthesis of antibiotics (presently produced via costly and environmentally unfriendly procedures), production of templates for modification into antibiotics/beta-lactamase inhibitors and which will make possible the commercial production of broad-spectrum beta-lactamase inhibitors. The CAS will utilise modified versions of natural enzymes involved in beta-lactic biosynthesis. The work will involve implementation of five Work Packages forming an integrated program with detailed structural, bioinorganic, engineering and fermentation studies on the relevant enzymes. The project will also produce a structural database for ferrous dependent oxygenases, define rules for engineering their selectivity and develop new methodology for crystallography and mutant screening.

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Coordinator

THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD

Address

South Parks Road
Ox1 3qt Oxford

United Kingdom

Participants (4)

AMURA LIMITED

United Kingdom

THE SWEDISH UNIVERSITY OF AGRICULTURAL SCIENCES

Sweden

UNIVERSITE DE LIEGE*ULG

Belgium

UPPSALA UNIVERSITY

Sweden

Project information

Grant agreement ID: QLK3-CT-2000-00513

  • Start date

    1 January 2001

  • End date

    31 December 2003

Funded under:

FP5-LIFE QUALITY

  • Overall budget:

    € 1 532 401

  • EU contribution

    € 1 366 200

Coordinated by:

THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD

United Kingdom