Objetivo This project will evaluate the hypothesis that Paths are the major source ofgenotoxic activities of organic mixtures associated with air pollution. Such exposures result in exogenous DNA damage but the importance of endogenous damages unknown. Exposure of 4 populations exposed to Paths will be measured and lifestyle factors determined. Exogenous exposure will be measured by determination of adducts, protein induction, and gene expression, and endogenous damage by measurement of oxidative DNA modification. Effect will be monitored by determination of chromosome aberration, and susceptibility by genotyping a wide variety of enzymes involved in carcinogen metabolism. Model in vitro cell systems will be proposed for studying the impact of Paths in complex mixtures of different air pollution origin. The project will define which biomarkers should be used for risk assessment of environmental exposure to Paths. Ámbito científico natural sciencesbiological sciencesgeneticsDNAengineering and technologyenvironmental engineeringair pollution engineeringnatural sciencesearth and related environmental sciencesenvironmental sciencespollutionnatural sciencesbiological sciencesgeneticschromosomesnatural sciencesbiological sciencesbiochemistrybiomoleculesproteinsenzymes Programa(s) FP5-LIFE QUALITY - Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002 Tema(s) 1.1.1.-4. - Key action Environment and Health Convocatoria de propuestas Data not available Régimen de financiación CSC - Cost-sharing contracts Coordinador MEDICAL RESEARCH COUNCIL Aportación de la UE Sin datos Dirección Lancaster Road University of Leicester Hodgkin Bui LE1 9HN Leicester Reino Unido Ver en el mapa Coste total Sin datos Participantes (6) Ordenar alfabéticamente Ordenar por aportación de la UE Ampliar todo Contraer todo CANCER RESEARCH INSTITUTE - SLOVAK ACADEMY OF SCIENCES Eslovaquia Aportación de la UE Sin datos Dirección 59,Vlarska 7 833 91 BRATISLAVA Ver en el mapa Coste total Sin datos GENETICS RESEARCH INSTITUTE ONLUS Italia Aportación de la UE Sin datos Dirección Strada Della Carita 10 20135 MILANO Ver en el mapa Coste total Sin datos INSTITUTE OF EXPERIMENTAL MEDICINE - ACADEMY OF SCIENCES OF THE CZECH REPUBLIC Chequia Aportación de la UE Sin datos Dirección Videnska 1083 142 20 PRAHA 4 Ver en el mapa Coste total Sin datos NATIONAL CENTRE FOR HYGIENE, MEDICAL ECOLOGY AND NUTRITION Bulgaria Aportación de la UE Sin datos Dirección 15,Dimitar Nestorov Boulevard 15 1431 SOFIA Ver en el mapa Coste total Sin datos THE HENRYK NIEWODNICZANSKI INSTITUTE OF NUCLEAR PHYSICS Polonia Aportación de la UE Sin datos Dirección 152,Radzikowskiego 152 31 342 KRAKOW Ver en el mapa Coste total Sin datos UNIVERSITY P.J. SAFARIK Eslovaquia Aportación de la UE Sin datos Dirección 1,Tr.Snp 1 040 60 KOSICE Ver en el mapa Coste total Sin datos