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Testing the mitochondrial theory of ageing

Project information

Grant agreement ID: QLK6-CT-2000-00054

  • Start date

    1 January 2001

  • End date

    31 December 2003

Funded under:

FP5-LIFE QUALITY

  • Overall budget:

    € 2 097 000

  • EU contribution

    € 1 800 000

Coordinated by:

UNIVERSITY OF TAMPERE

Finland

Objective

The mitochondria theory of ageing proposes that the accumulation of somatic mutations in mitochondria DNA during life results in a progressive decline in energetic function and eventual cellular and organism senescence. We propose to test this idea directly, by engineering and expressing a version of the mitochondria DNA polymerise POLG that lacks proofreading exonuclease activity, and hence results in the rapid accumulation of medina mutations. This medina matador will be created and tested in parallel in four model systems: yeast, the mouse, cultured human cells and the fruit fly Drosophilae. The phenotypic consequences of an enhanced rate of accumulation of medina mutations will be investigated via studies of cellular bioenergetics function, ageing-related physiological decline and tissue degeneration, alterations in the pattern of gene expression, and overall lifespan.

Coordinator

UNIVERSITY OF TAMPERE

Address

6,LenkkeilijÄNkatu 6
33014 Tampere

Finland

Participants (4)

ASTRA ZENECA AB

Sweden

KAROLINSKA INSTITUTE

Sweden

UNIVERSIDAD AUTONOMA DE MADRID

Spain

UNIVERSITE CATHOLIQUE DE LOUVAIN

Belgium

Project information

Grant agreement ID: QLK6-CT-2000-00054

  • Start date

    1 January 2001

  • End date

    31 December 2003

Funded under:

FP5-LIFE QUALITY

  • Overall budget:

    € 2 097 000

  • EU contribution

    € 1 800 000

Coordinated by:

UNIVERSITY OF TAMPERE

Finland