Reperfusion/reperfusion injury is a well-known feature of acute/chronic renal dysfunction, known as acute renal failure (ARF), with 1-5% of hospitalised patients being affected. This is a major social economic problem of the ageing population and patients receiving kidney transplantation (cold schema), a demand increasing with age. ARF is associated with cell death by apoptosis or necrosis. Currently we do not know the impact of initiating and/or interrelated events during the onset and progression of ARF. It is imperative to characterize a sequence of events that links primary damaging components such as an unbalanced NO/O>2 - and/or xanthenes/adenosine ratio to an end stage injury. 4 groups that are recognized for cutting edge science will carry experiments out in-vivo and in-vitro using rodent material. The outcome of the project will be the establishment of an early index of cell death with the opportunity to intervene pharmacologically, thereby preventing progression of cell injury once initiated. The application of such newly established prognostic parameters to human subjects would serve to predict the severity of renal injury inhuman and open avenues for novel therapeutic interventions.
Funding SchemeCSC - Cost-sharing contracts
W12 0NN London