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Hypoxic renal injury

Objective

Reperfusion/reperfusion injury is a well-known feature of acute/chronic renal dysfunction, known as acute renal failure (ARF), with 1-5% of hospitalised patients being affected. This is a major social economic problem of the ageing population and patients receiving kidney transplantation (cold schema), a demand increasing with age. ARF is associated with cell death by apoptosis or necrosis. Currently we do not know the impact of initiating and/or interrelated events during the onset and progression of ARF. It is imperative to characterize a sequence of events that links primary damaging components such as an unbalanced NO/O>2 - and/or xanthenes/adenosine ratio to an end stage injury. 4 groups that are recognized for cutting edge science will carry experiments out in-vivo and in-vitro using rodent material. The outcome of the project will be the establishment of an early index of cell death with the opportunity to intervene pharmacologically, thereby preventing progression of cell injury once initiated. The application of such newly established prognostic parameters to human subjects would serve to predict the severity of renal injury inhuman and open avenues for novel therapeutic interventions.

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS
Address
18-26,Roselló, 161 7 Planta
08036 Barcelona
Spain

Participants (3)

IMPERIAL COLLEGE OF SCIENCE, TECHNOLOGY AND MEDICINE
United Kingdom
Address
Du Cane Road
W12 0NN London
UNIVERSITAET KAISERSLAUTERN
Germany
Address
Erwin-schroediger-strasse
67663 Kaiserslautern
UNIVERSITE DE POITIERS
France
Address
Rue Du Jardin Des Plantes 34
86005 Poitiers