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The genetic control of brain development

The genetic control of brain development

Objective

Primary regional organisation of the vertebrate brain is specified by gene cascades, which reactivated during early embryogenesis. Identities of different brain regions are partly defined by gene families having similar functions in Drosophilae and vertebrates, indicating regulatory mechanisms that are strongly conserved in evolution. Despite fragmentary knowledge about different aspects of early neural development, there is not yet an integrated picture of the regulatory cascades which set-up the primary organisation of the brain. This is a central unsolved problem in the neurosciences. The proposed programme coordinates the complementary expertises of six specialist groups to elucidate mechanisms underlying development of different brain regions and determine how their construction is coordinated. We expect that these investigations will provide a solid basis for understanding how the brain is built and how its organisation is disturbed by genetic disease.

Coordinator

NETHERLANDS INSTITUTE FOR DEVELOPMENTAL BIOLOGY

Address

8,Uppsalalaan 8
3584 Ct Utrecht

Netherlands

Administrative Contact

Ronald PLASTERK (Prof.)

Participants (5)

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INSTITUT PASTEUR

France

MAX-PLANCK-GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V.

Germany

MRC National Institute for Medical Research

United Kingdom

UNIVERSIDAD MIGUEL HERNANDEZ DE ELCHE

Spain

UNIVERSITA VITA-SALUTE SAN RAFFAELE

Italy

Project information

Grant agreement ID: QLG3-CT-2000-01625

  • Start date

    1 January 2001

  • End date

    31 December 2004

Funded under:

FP5-LIFE QUALITY

  • Overall budget:

    € 2 000 721

  • EU contribution

    € 1 467 024

Coordinated by:

NETHERLANDS INSTITUTE FOR DEVELOPMENTAL BIOLOGY

Netherlands