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Adhesive interactions in malaria: new targets for intervention

Objective

Drugs against malaria are urgently needed. The morbidity and mortality inflicted by tropical malaria is associated with the adhesive properties of erythrocytes infected with the malarial parasite Plasmodium falciparum. Sequestration of infected erythrocytes severely compromises the host, resulting in damage to vital organs including the brain. The objective of this research proposal is to develop the technological and scientific base that will permit the rational design ofanti-adhesive drugs for the treatment of severe malaria. This includes a strong research initiative to
I) dissect the mechanism of differential vary gene expression;
ii) better define the receptor-legend interactions involved in adhesion;
iii) investigate post-adhesive events that lead to pathogenesis; and iv)develop an adhesion-disruptive receptor-mimicking carbohydrate. This consortium brings together the leading European scientists in these research areas .

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Coordinator

UNIVERSITAETSKLINIKUM HEIDELBERG

Address

Im Neuenheimer Feld 324
69120 Heidelberg

Germany

Administrative Contact

Hermann FUNK (Professor)

Participants (6)

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4SC AG

Germany

INSTITUT PASTEUR

France

KAROLINSKA INSTITUTE

Sweden

LIVERPOOL SCHOOL OF TROPICAL MEDICINE

United Kingdom

RUPRECHT-KARLS-UNIVERSITAET HEIDELBERG

Germany

UNIVERSITE DE LA MEDITERRANEE D'AIX-MARSEILLE II

France

Project information

Grant agreement ID: QLK2-CT-2000-00109

  • Start date

    1 September 2000

  • End date

    30 November 2003

Funded under:

FP5-LIFE QUALITY

  • Overall budget:

    € 1 379 944

  • EU contribution

    € 1 300 000

Coordinated by:

UNIVERSITAETSKLINIKUM HEIDELBERG

Germany