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Bacterial two-component systems as targets for the development of novel antibacterials and anti-infectives.

Objective

Microbial drug resistance imposes an increasing threat to human and animal health and the development of new drugs to control bacterial infections is therefore urgently needed. The overall objective of this project is to exploit a new class of bacterial targets called two-component systems (TCS) for the development of novel antibacterial and drugs that specifically target the mechanisms by which bacteria establish infection in the host. This objective will be achieved by targeting pan-European critical mass, expertise and support to understanding of the structure, function and biological diversity of these targets. By the end of the project we will expect to have selected appropriate targets and have developed selective assays for inhibitors of those targets that can be used for high throughput screening in the pharmaceutical industry.

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

INSTITUTE OF FOOD RESEARCH
Address
Norwich Research Park, Colney
Norwich
United Kingdom

Participants (5)

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
France
Address
Route De Narbonne 118 Univ. P.sabatier Toulouse 3
31062 Toulouse
CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS
Spain
Address
144,Velazquez 144
28006 Madrid
UNIVERSITE PAUL SABATIER DE TOULOUSE III
France
Address
Route De Narbonne 118
31062 Toulouse
UNIVERSITY OF GLASGOW
United Kingdom
Address
University Avenue
Glasgow
UNIVERSITÀ DEGLI STUDI DI SIENA
Italy
Address
Viale Bracci Policlinico Dellle Scotte
53100 Siena