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Replication initiation proteins as new targets for bacterial growth inhibition

Project information

Grant agreement ID: QLK2-CT-2000-00634

  • Start date

    1 September 2000

  • End date

    31 August 2003

Funded under:

FP5-LIFE QUALITY

  • Overall budget:

    € 2 864 295

  • EU contribution

    € 2 009 999

Coordinated by:

CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS

Spain

Objective

There is an urgent need for the discovery of novel antibacterial compounds to combat deadly emulate-drug resistant strains. Our targets are the proteins of initiation of DNA replication (IDR).Since they differ substantially in bacteria and eucalypts the bacterial IDR proteins constitute unattractive and unexplored family of targets for development of new antibiotics which is the essence of our proposal. The novelty of this approach lies in the development of assays to highlight the inhibition of IDR proteins and in the identification and/or design of compounds, which target IDRproteins. Our objective is to engineer bacterial strains for in vivo screening and in vitro biochemical detection methods for the identification of novel inhibitors of DNA replication initiation. High-throughput screening (HTS) and detailed structure-activity knowledge of the IDR protein inhibitors will bemused for synthetic modifications to enhance the specificity of targeting.

Coordinator

CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS

Address

Campus De La Universidad Autonoma De Madrid
28049 Madrid

Spain

Participants (6)

COMBINATURE BIOPHARM AG

Germany

FREIE UNIVERSITAET BERLIN

Germany

INSTITUTE FOR CANCER RESEARCH

Norway

MAX-PLANCK-GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V.

Germany

UNIVERSITY OF SHEFFIELD

United Kingdom

UTRECHT UNIVERSITY

Netherlands

Project information

Grant agreement ID: QLK2-CT-2000-00634

  • Start date

    1 September 2000

  • End date

    31 August 2003

Funded under:

FP5-LIFE QUALITY

  • Overall budget:

    € 2 864 295

  • EU contribution

    € 2 009 999

Coordinated by:

CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS

Spain