Objectif the present number one threat to human health is recognized as being the previously unseen levels of multiple antibiotic resistances that exist in bacterial pathogens. The development of new antibiotics is of crucial importance. Unfortunately, the mechanism of action of commonly used antibiotics is not fully understood. Understanding the molecular mechanisms of antibiotic action and resistance will make the rational design of new drugs possible. We aim to elucidate the structural origins for the action and resistance of a class of antibiotics, the macrolides.They interact with the RNA component of ribosomes and inhibit protein synthesis. The latest generation of macro ides, the deltoids, exhibit high activity againstmacrolides-resistant bacterial strains . A combination of genetic , biochemical and structural tools originating from different groups will be use used. Structural data will be essential for the development of new therapeutic agents. Champ scientifique medical and health sciencesbasic medicinepharmacology and pharmacydrug discoverynatural sciencesbiological sciencesmicrobiologybacteriologymedical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsantibioticsnatural sciencesbiological sciencesgeneticsRNAmedical and health sciencesbasic medicinepharmacology and pharmacydrug resistanceantibiotic resistance Programme(s) FP5-LIFE QUALITY - Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002 Thème(s) 1.1.1.-2. - Key action Control of Infectious Diseases Appel à propositions Data not available Régime de financement CSC - Cost-sharing contracts Coordinateur Centre National de la Recherche Scientifique (CNRS) Contribution de l’UE Aucune donnée Adresse Avenue de la Terrasse 91198 Gif-sur-Yvette France Voir sur la carte Coût total Aucune donnée Participants (2) Trier par ordre alphabétique Trier par contribution de l’UE Tout développer Tout réduire UNIVERSITY OF SOUTHERN DENMARK - UNIVERSITY OF ODENSE Danemark Contribution de l’UE Aucune donnée Adresse 55,Campusvej 55 5230 ODENSE Voir sur la carte Coût total Aucune donnée UNIVERSITY OF TARTU Estonie Contribution de l’UE Aucune donnée Adresse 23,Riia Street 23 51010 TARTU Voir sur la carte Coût total Aucune donnée
