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Human pneumocystis carinii infection in immunocompetent hosts : a public health issue in europe

Objective

This project is the first multimember study on sub clinical P. carina (PC) infection in the general population, in which genotypical,phenotypical and clinical aspects are combined in order to assess its importance for public health. General objective: to provide new knowledge on the epidemiology and the clinical impact of PC-infection in Europe. Specific objectives:
1)To investigate the prevalence of PC sub clinical infection in subjects with chronic bronchial disease and in healthy individuals from Europe and its correlation with environmental factors;
2) To draw an epidemiological map of PC genotypes;
3) To explore genomic and phenotypic differences between PC from carriers and from PC pneumonia patients;
4) To characterise the immune response against PC infection in subjects which develop pneumonia, remain as carriers or eliminate the infection;
5) Defining the role of immunological mechanisms of protection against human PC infection; d) Definition of the role of the PC infection in the evolution of CBD and the role of PC carriers in the parasite transmission.

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

SERVICIO ANDALUZ DE SALUD
Address
Avenida Manuel Siurot S/n
41013 Sevilla
Spain

Participants (9)

CATHOLIC UNIVERSITY OF SACRED HEART
Italy
Address
Largo Francesco Vito 1
00168 Roma
CENTRE HOSPITALIER UNIVERSITAIRE D' AMIENS
France
Address
Rue Laennec
80054 Amiens
CENTRE HOSPITALIER UNIVERSITAIRE VAUDOIS
Switzerland
Address
Rue Du Bugnon 44 (Imu)
1011 Lausanne
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France
Address
Place Du Docteur Baylac Adr 4 - Midi-pyrénées Hô
31059 Toulouse
INSTITUT PASTEUR DE LILLE
France
Address
1,Rue Du Professeur Calmette 1
59019 Lille
STATENS SERUM INSTITUT
Denmark
Address
5,Artillerivej 5
2300 Koepenhagen
UNIVERSIDADE NOVA DE LISBOA
Portugal
Address
96,Rua De Junqueira 96
1349-008 Lisboa
UNIVERSITE CLAUDE BERNARD LYON 1
France
Address
Boulevard Du 11 Novembre 1918, 43
69622 Villeurbanne
UNIVERSITE PIERRE ET MARIE CURIE - PARIS VI
France
Address
Place Jussieu 4
75252 Paris