Objectif HVC is a growing European medical problem here there is no effective long-term therapy. Mostly fatal, this infectious disease may be chronically carried by 5 million Europeans placing a huge burden on medical services and resources. Novel and effective antiviral therapies are therefore urgently needed. We use rational drug design to develop new drugs to combat HCV at a critical stage in its life cycle. Our dugs fit a specific target in the RNA structure, freezing its shape, it is no longer able to bind its native protein, and thus viral replication is inhibited. We will determine the 3D structure of the RNA target, design and make novel drugs, develop assays to measure inhibition of RNA function, and make through iterative cycles lead molecules. In collaboration withal pharmaceutical partner such drugs would be entered into a clinical evaluation programme. This research will benefit Europeans by producing novel therapies to this debilitating and often fatal disease. Champ scientifique medical and health sciencesbasic medicinemedicinal chemistrymedical and health scienceshealth sciencesinfectious diseasesRNA viruseshepatitis Cnatural sciencesbiological sciencesbiochemistrybiomoleculesproteinsnatural sciencesbiological sciencesgeneticsRNA Programme(s) FP5-LIFE QUALITY - Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002 Thème(s) 1.1.1.-2. - Key action Control of Infectious Diseases Appel à propositions Data not available Régime de financement CSC - Cost-sharing contracts Coordinateur VERNALIS (CAMBRIDG) LIMITED Contribution de l’UE Aucune donnée Adresse Granta Park, Abington CB1 6GB CAMBRIDGE Royaume-Uni Voir sur la carte Coût total Aucune donnée Participants (4) Trier par ordre alphabétique Trier par contribution de l’UE Tout développer Tout réduire CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE France Contribution de l’UE Aucune donnée Adresse 15,Rue René Descartes 15 67084 Strasbourg Voir sur la carte Coût total Aucune donnée GENT UNIVERSITY Belgique Contribution de l’UE Aucune donnée Adresse Krijgslaan 281 S4 9000 GENT Voir sur la carte Coût total Aucune donnée TECHNICAL UNIVERSITY OF MUNICH Allemagne Contribution de l’UE Aucune donnée Adresse Lichtenbergstrasse 4 85747 Garching Voir sur la carte Coût total Aucune donnée UNIVERSITE LOUIS PASTEUR, STRASBOURG 1 France Contribution de l’UE Aucune donnée Adresse Rue Blaise Pascal 4 67070 STRASBOURG Voir sur la carte Coût total Aucune donnée
