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Therapeutic oligomers for in vivo targeted gene modification

Therapeutic oligomers for in vivo targeted gene modification

Objective

We work towards a platform technology that allows high efficiency targeted gene modification, including repair of mutated genes in the genome of humans but also site specific autogenesis in living cells at will. For this aim we develop a novel class of sequence specific bioactive molecules: Therapeutic Repair Bloomers (Taros). Taros are able to recognize a particular DNA sequence and to induce specific sequence changes. The outcome of our research will have profound implications for human gene therapy by eliminating the need of introducing foreign genes. For plant breeding the platform technology will have the potential of creating new consumer friendly traits based on single point mutations.

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Coordinator

THE NATIONAL HOSPITAL UNIVERSITY OF OSLO

Address

Gaustad
0027 Oslo

Norway

Administrative Contact

Stefan KRAUSS (Prof)

Participants (6)

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CHALMERS UNIVERSITY OF TECHNOLOGY

Sweden

LINK TECHNOLOGIES LIMITED

United Kingdom

UNIVERSITY OF COPENHAGEN

Denmark

UNIVERSITY OF OSLO

Norway

UNIVERSITY OF SOUTHAMPTON

United Kingdom

UNIVERSITY OF ZURICH

Switzerland

Project information

Grant agreement ID: QLK3-CT-2000-00634

  • Start date

    1 February 2001

  • End date

    31 January 2004

Funded under:

FP5-LIFE QUALITY

  • Overall budget:

    € 2 393 794

  • EU contribution

    € 1 964 544

Coordinated by:

THE NATIONAL HOSPITAL UNIVERSITY OF OSLO

Norway