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The European sulfolobus project. Screening for and expressing thermostable enzymes of industrial interest from sulfolobus and other crenarchaeotes

The European sulfolobus project. Screening for and expressing thermostable enzymes of industrial interest from sulfolobus and other crenarchaeotes

Objective

The Crenarchaeotes constitute a kingdom of the Archaea that contains a very diverse range of microorganisms many of which are extreme- or hyperthermophiles. They differ extensively genetically and biochemically from Bacteria and Eukaryotes. Sulfolobus is the best studied of these organisms and most of ground-breaking work on this organism has been done in Europe. The purpose of this project is to exploit this European advantage and to screen for novel enzyme activities both at the genomic level and in an extensive and unique European collection of thermophilic Crenarchaeotes. Moreover, we will develop and refine vector systems for expressing these proteins in a range of Bacterial and Eukaryotic hosts by modifying the Archaeal genetic signals. In particular, we will develop, for the first time, a vector-host system for expressing Crenarchaeal enzymes in Sulfolobus on a large scale.

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Coordinator

UNIVERSITY OF COPENHAGEN

Address

Oester Voldgade 3
1350 Koebenhavn K/Copenhaegen

Denmark

Administrative Contact

Eliszabeth BRUUN (Professor)

Participants (8)

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EPIDAUROS BIOTECHNOLOGIE AG

Germany

MICROBIOLOGICAL RESEARCH AUTHORITY

United Kingdom

NOVOZYMES A/S

Denmark

TECHNICAL UNIVERSITY OF DENMARK

Denmark

UNIVERSITA DEGLI STUDI DI NAPOLI FEDERICO II

Italy

UNIVERSITAET DARMSTADT/TU

Germany

UPPSALA UNIVERSITY

Sweden

WAGENINGEN UNIVERSITY

Netherlands

Project information

Grant agreement ID: QLK3-CT-2000-00649

  • Start date

    1 January 2001

  • End date

    29 February 2004

Funded under:

FP5-LIFE QUALITY

  • Overall budget:

    € 2 424 263

  • EU contribution

    € 1 827 031

Coordinated by:

UNIVERSITY OF COPENHAGEN

Denmark