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Disease insights from single cell signaling

Project information

Grant agreement ID: QLK3-CT-2000-01038

  • Start date

    1 December 2000

  • End date

    30 November 2003

Funded under:

FP5-LIFE QUALITY

  • Overall budget:

    € 1 696 598

  • EU contribution

    € 907 312

Coordinated by:

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE

France

Objective

Signalling cascades play multiple roles in cell growth, differentiation and death. Their perturbation has profound consequences linked to diseases such as cancer, myopathy and diabetes, major health concerns in Europe. We propose to develop and implement nana technologies, which allow monitoring and examination of intracellular signalling processes in real time at the single cell level. Ourgoals are to create detailed molecular maps of the temporal and spatial organization of proteins involved in signal transudation, in particular insulinsignaling. With this information we can compare diseased and normal tissue to identify specific errors in signalling cascades. Moreover, we can directly development-animal based assays for use in drug discovery. Once established this Nan technology can be extended to the analysis of diverse signalling cassettes in variety of other diseases of high social and economic impact in Europe.

Coordinator

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE

Address

Rue De La Cardonille 141
34396 Montpellier

France

Participants (5)

CANCER RESEARCH UK

United Kingdom

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE

France

KATHOLIEKE UNIVERSITEIT LEUVEN

Belgium

NOVARTIS FORSCHUNGSSTIFTUNG, ZWEIGNIEDERLASSUNG FRIEDRICH MIESCHER-INSTITUT FOR BIOMEDICAL RESEARCH

Switzerland

NOVO-NORDISK A/S

Denmark

Project information

Grant agreement ID: QLK3-CT-2000-01038

  • Start date

    1 December 2000

  • End date

    30 November 2003

Funded under:

FP5-LIFE QUALITY

  • Overall budget:

    € 1 696 598

  • EU contribution

    € 907 312

Coordinated by:

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE

France