Objective The project regroups the laboratories of M. Zola (I), D. Rubinsztein (UK), J.P. Changeup (F), K. Fuse (S), P. Inciter (D) and P. Moser (Synthelabo Recherché, F). Its aim is to explore the role of nicotinic acetylcholine receptors (nAChR) in brain ageing and related deficits. The workplan includes:1. To study,whether polymorphisms in nAChR genes influence the rate of cognitive decline in the elderly;2. To characterise the molecular mechanisms of nicotine neuroprotection and neurodegeneration caused by nAChR deficits in animal models, including the study ofa. the influence of nacho isotopes on brain ageing using nacho subunit mutant mice,b. the interaction between nacho deficits and other age-related pathogenic factors (e.g. amyloidal beta protein and tropic factors),c. the influence of nacho deficits on neuronal apoptosis, and d. the comparative genomic of ageing in humans and nacho mutant mice;3. To characterise new, nicotinic agents for the therapy of age-related neurodegeneration and cognitive deficits. Fields of science natural sciencesbiological sciencesneurobiologynatural sciencesbiological sciencesbiochemistrybiomoleculesproteins Programme(s) FP5-LIFE QUALITY - Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002 Topic(s) 1.1.1.-6. - Key action The Ageing Population and Disabilities Call for proposal Data not available Funding Scheme CSC - Cost-sharing contracts Coordinator UNIVERSITY OF MODENA AND REGGIO EMILIA EU contribution No data Address Via g.campi 287 41100 Modena Italy See on map Total cost No data Participants (5) Sort alphabetically Sort by EU Contribution Expand all Collapse all INSTITUT PASTEUR France EU contribution No data Address 25,rue du docteur roux 25 75724 Paris See on map Total cost No data KAROLINSKA INSTITUTE Sweden EU contribution No data Address Berzelius väg 3 171 77 Stockholm See on map Total cost No data MEDICAL RESEARCH COUNCIL United Kingdom EU contribution No data Address Lancaster road university of leicester hodgkin bui LE1 9HN Leicester See on map Total cost No data SANOFI-SYNTHELABO RECHERCHE France EU contribution No data Address Avenue paul vaillant-couturier 31 92225 Bagneux See on map Total cost No data THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE United Kingdom EU contribution No data Address Hills road, addenbrooke's hospital, wellcome trust CB2 2XY Cambridge See on map Total cost No data