Obiettivo The project regroups the laboratories of M. Zola (I), D. Rubinsztein (UK), J.P. Changeup (F), K. Fuse (S), P. Inciter (D) and P. Moser (Synthelabo Recherché, F). Its aim is to explore the role of nicotinic acetylcholine receptors (nAChR) in brain ageing and related deficits. The workplan includes:1. To study,whether polymorphisms in nAChR genes influence the rate of cognitive decline in the elderly;2. To characterise the molecular mechanisms of nicotine neuroprotection and neurodegeneration caused by nAChR deficits in animal models, including the study ofa. the influence of nacho isotopes on brain ageing using nacho subunit mutant mice,b. the interaction between nacho deficits and other age-related pathogenic factors (e.g. amyloidal beta protein and tropic factors),c. the influence of nacho deficits on neuronal apoptosis, and d. the comparative genomic of ageing in humans and nacho mutant mice;3. To characterise new, nicotinic agents for the therapy of age-related neurodegeneration and cognitive deficits. Campo scientifico natural sciencesbiological sciencesneurobiologynatural sciencesbiological sciencesbiochemistrybiomoleculesproteins Programma(i) FP5-LIFE QUALITY - Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002 Argomento(i) 1.1.1.-6. - Key action The Ageing Population and Disabilities Invito a presentare proposte Data not available Meccanismo di finanziamento CSC - Cost-sharing contracts Coordinatore UNIVERSITY OF MODENA AND REGGIO EMILIA Contributo UE Nessun dato Indirizzo Via g.campi 287 41100 Modena Italia Mostra sulla mappa Costo totale Nessun dato Partecipanti (5) Classifica in ordine alfabetico Classifica per Contributo UE Espandi tutto Riduci tutto INSTITUT PASTEUR Francia Contributo UE Nessun dato Indirizzo 25,rue du docteur roux 25 75724 Paris Mostra sulla mappa Costo totale Nessun dato KAROLINSKA INSTITUTE Svezia Contributo UE Nessun dato Indirizzo Berzelius väg 3 171 77 Stockholm Mostra sulla mappa Costo totale Nessun dato MEDICAL RESEARCH COUNCIL Regno Unito Contributo UE Nessun dato Indirizzo Lancaster road university of leicester hodgkin bui LE1 9HN Leicester Mostra sulla mappa Costo totale Nessun dato SANOFI-SYNTHELABO RECHERCHE Francia Contributo UE Nessun dato Indirizzo Avenue paul vaillant-couturier 31 92225 Bagneux Mostra sulla mappa Costo totale Nessun dato THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE Regno Unito Contributo UE Nessun dato Indirizzo Hills road, addenbrooke's hospital, wellcome trust CB2 2XY Cambridge Mostra sulla mappa Costo totale Nessun dato