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New generation genetic markers and techniques for the epidemiology and control of tuberculosis

New generation genetic markers and techniques for the epidemiology and control of tuberculosis

Objective

DNA fingerprint techniques have been developed to type Mycobacterium tuberculosis isolates for studying the molecular epidemiology of tuberculosis. The previous Subprojects have promoted optimal communication between EU partners, thus enabling standardization of these methods, and meaningful interpretation and comparison of results from epidemiological studies in different areas. In this project we plant maintain the established network in Europe and to use the DNA fingerprint databases to trace transmission of strains, including multidrug resistant strains internationally, and to study the natural history and control of tuberculosis. Furthermore, we aim to test the potential of novel genetic markers, derived from the recently established genome sequence of M. tuberculosis, and to explore Dacha and micro array technology to allow use of multiple genetic markers with different molecular clocks.

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Coordinator

NATIONAL INSTITUTE OF PUBLIC HEALTH AND ENVIRONMENT

Address

9,Antonie Van Leeuwenhoeklaan 9
3720 Ba Bilthoven

Netherlands

Administrative Contact

Gijs ELZINGA (Dr.)

Participants (30)

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ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS

France

AYUNTAMIENTO DE BARCELONA

Spain

CENTERS FOR DISEASE CONTROL AND PREVENTION

United States

HOWARD HUGUES MEDICAL INSTIUTE

United States

INSTITUT DE VEILLE SANITAIRE

France

INSTITUT PASTEUR

France

INSTITUT PASTEUR DE BRUXELLES

Belgium

INSTITUT PASTEUR DE GUADELOUP

France

INSTITUT PASTEUR DE LILLE

France

INSTITUTE OF HEALTH CARLOS III

Spain

INSTITUTE OF TROPICAL MEDICINE PRINCE LEOPOLD

Belgium

INSTITUTO NACIONAL DE SAUDE

Portugal

KAROLINSKA INSTITUTE

Sweden

KONINLIJKE NEDERLANDSE CENTRALE VERINIGING TOT BESTRIJDING DER TUBERCULOSE

Netherlands

LEOPOLD-FRANZENS-UNIVERSITAET INNSBRUCK

Austria

LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE

United Kingdom

NATIONAL INSTITUTE OF PUBLIC HEALTH

Czechia

NORWEGIAN INSTITUTE OF PUBLIC HEALTH

Norway

PUBLIC HEALTH LABORATORY - TEL AVIV

Israel

PUBLIC HEALTH RESEARCH INSTITUTE

United States

RESEARCH CENTER BORSTEL, CENTER FOR MEDICINE AND BIOLOGICAL SCIENCE

Germany

RUPRECHT-KARLS-UNIVERSITAET HEIDELBERG

Germany

STANFORD UNIVERSITY

United States

STATENS SERUM INSTITUT

Denmark

THE UNIVERSITY OF MILANO

Italy

UNIVERSIDAD DE ZARAGOZA

Spain

UNIVERSIDADE DE LISBOA

Portugal

UNIVERSITY OF LAS PALMAS DE GRAN CANARIA

Spain

UNIVERSITY OF STELLENBOSCH

South Africa

UNIVERSITY OF SURREY

United Kingdom

Project information

Grant agreement ID: QLK2-CT-2000-00630

  • Start date

    1 October 2000

  • End date

    31 December 2003

Funded under:

FP5-LIFE QUALITY

  • Overall budget:

    € 894 088

  • EU contribution

    € 894 088

Coordinated by:

NATIONAL INSTITUTE OF PUBLIC HEALTH AND ENVIRONMENT

Netherlands