Objective This proposal is related to zoometric coetaneous leishmaniasis (ZCL) which remains a serious unresolved public health problem worldwide. The project consists to refine the validity of classical (leishmanin skin test) and new (antibodies to sand flysaliva, cytotoxic Tcell response) parameters for a better understanding of thepathogenesis of L. major infection and to develop mathematical models for the prediction of the dynamics of infection and the outcome of control measures. The study design consists of a prospective population study of individuals living into different ZCL foci. The effect of host-related factors on the clinical expression of the infection will be assessed considering environmental factors. This will permit a better knowledge of key parameters governing dynamics of infection and will prepare the ground for better evaluation of anti-leishmanialdrugs and vaccines. Fields of science medical and health scienceshealth sciencespublic healthmedical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsvaccinesnatural sciencesmathematicsapplied mathematicsmathematical model Programme(s) FP5-INCO 2 - Programme for research, technological development and demonstration on "Confirming the international role of Community research,1998-2002" Topic(s) Data not available Call for proposal Data not available Funding Scheme CSC - Cost-sharing contracts Coordinator IMPERIAL COLLEGE OF SCIENCE, TECHNOLOGY AND MEDICINE EU contribution No data Address Campus at Silwood Park, Road A329 (Virginia Water SW7 2AZ LONDON United Kingdom See on map Total cost No data Participants (3) Sort alphabetically Sort by EU Contribution Expand all Collapse all ACADEMISCH ZIEKENHUIS BIJ DE UNIVERSITEIT VAN AMSTERDAM Netherlands EU contribution No data Address Meibergdreef 9, Academisch Medisch Centrum 1105 AZ AMSTERDAM See on map Total cost No data INSTITUT PASTEUR DE TUNIS Tunisia EU contribution No data Address Place Pasteur 13 1002 TUNIS See on map Total cost No data MINISTRY OF HEALTH OF JORDAN Jordan EU contribution No data Address Khalid Bin Al-Walid AMMAN See on map Total cost No data