Exploitation of key enzymes in the isoprenoid biosynthetic pathway as drug targets in leishmania

Informazioni relative al progetto

SQS/LEISHMANIA

ID dell’accordo di sovvenzione: ICA4-CT-2001-10074

Data di avvio 1 Settembre 2001

Data di completamento 28 Febbraio 2005

Finanziato da

• Programme for research, technological development and demonstration on "Confirming the international role of Community research,1998-2002"

Costo totale € 1 049 786,00

Contributo UE € 795 734,00

Coordinato da

CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS
Spain

Obiettivo

The proposal describes how steps will be made to advance in the knowledge of is oprenoid biosynthesis in order to produce specific inhibitors that will be of use in the treatment of the leishamniases. Focus will be placed on the development of inhbitors against two enzymes: farnesyl diphosphate syntheses and squalling syntheses. Advantage will be taken of the existing knowledge on the inhibition of these enzymes in other organisms and of the crystal structures available for the modelling of the active site of the protozoan enzymes and identification of lead molecules. Alterations in is oprenoid composition, effects on parasite ultrustructural morphology and the intracellular localization of these enzymes will be studied in order to use the information in understanding drug toxicity, mode of action and intracellular transport requirements.

Campo scientifico

• engineering and technology › materials engineering › crystals
• natural sciences › biological sciences › biochemistry › biomolecules › proteins › enzymes

Programma(i)

• FP5-INCO 2 - Programme for research, technological development and demonstration on "Confirming the international role of Community research,1998-2002"

Argomento(i)

Data not available

Invito a presentare proposte

Data not available

Meccanismo di finanziamento

CSC - Cost-sharing contracts

Coordinatore

CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS

• Contributo UE: Nessun dato
• Indirizzo: Calle Ventanilla 11 ; 18001 GRANADA ; Spagna
• Costo totale: Nessun dato

Partecipanti (3)

FEDERAL UNIVERSITY OF RIO DE JANEIRO

Brasile

• Contributo UE: Nessun dato
• Indirizzo: S/N,Edificio do Centro de Ciencias da Saude, Bloco G ; 21949-900 RIO DE JANEIRO
• Costo totale: Nessun dato

INSTITUTO VENEZOLANO DE INVESTIGACIONES CIENTIFICAS

Venezuela

• Contributo UE: Nessun dato
• Indirizzo: KM 11,Altos de Pipe, KM. 11, Carretera Panamericana ; 1020 CARACAS
• Costo totale: Nessun dato

UNIVERSITY OF WALES CARDIFF

Regno Unito

• Contributo UE: Nessun dato
• Indirizzo: King Edward VII Avenue, Redwood Building ; CF10 3XF CARDIFF
• Costo totale: Nessun dato