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Discovery of a new class of bioactive compounds:bacterial conjugation inhibitors

Discovery of a new class of bioactive compounds:bacterial conjugation inhibitors

Objective

Combating bacteria with antibiotics directly cannot be effective in the long run because bacteria acquire antibiotic resistance (AR) genes easily from surrounding pools of resistant bacteria. Thus, an appropriate long-term public health objective would be to fight bacteria AND the mechanisms of AR acquisition with coordinated strategy. Acquisition of AR genes occurs primarily by the mechanism of bacterial conjugation. Preventing conjugation should markedly limit the dissemination of AR. This project's primary aim is to devise the most effective strategy to inhibit conjugation in or around the bacterial targets where AR is undesirable. For this purpose, we will isolate and characterize broad range conjugation inhibitors, test them in four model environments, and improve them by rational design. Administration of an antibiotic together with, or preceded by, administration of a conjugation inhibitor should prevent AR acquisition

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Coordinator

UNIVERSIDAD DE CANTABRIA

Address

S/N,C/ Herrera Oria S/N
39011 Santander

Spain

Administrative Contact

Juan JORDA (Prof.)

Participants (6)

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CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS

Spain

CUBIST PHARMACEUTICALS (UK) LIMITED

United Kingdom

INSTITUT FUER CHEMIE

Austria

INSTITUT FUER MOLEKULARBIOLOGIE, BIOCHEMIE UND MIKROBIOLOGIE

Austria

MAX-PLANCK-GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V.

Germany

TECHNICAL UNIVERSITY OF DENMARK

Denmark

Project information

Grant agreement ID: QLK2-CT-2000-01624

  • Start date

    1 April 2001

  • End date

    31 March 2003

Funded under:

FP5-LIFE QUALITY

  • Overall budget:

    € 853 565

  • EU contribution

    € 500 000

Coordinated by:

UNIVERSIDAD DE CANTABRIA

Spain